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Global Collagen And HA-Based Biomaterials Industry

2. MARKET TRENDS AND ISSUES II-8Increasing Preference for Shorter and Convenient TreatmentOptions II-8Manufacturers Target Private Healthcare Market II-8Population/Baby Boomers Play a Major Role II-8Injectables Market on a High Growth Curve II-8Skin Care Products Continue to Dominate Cosmeceuticals II-9Hyaluronic-Acid Based Products Replace Other Facial ImplantProducts II-9Biomaterial Research Develops New Applications II-9Issues and Threats II-10Potential Shortage of Biomaterials II-10Inadequate Reimbursements II-10

3. BIOMATERIALS - A BRIEF OVERVIEW II-11Definition II-11Types of Biomaterials for Medical Devices II-11Polymers II-11Composites II-11Metals & Alloys II-11Ceramics II-12Biological Biomaterials II-12Application of Various Forms of Biomaterials II-12Collagen & Ha-Based Biomaterials II-12Collagen Based Biomaterials II-13What is Collagen? II-13Collagen-Based Biomaterials II-13Various Forms of Collagen and Applications II-14Soft Tissue Fillers Offer Patients More Options II-14Threatened by Alternatives II-14Hyaluronic Acid (HA) II-14Table 3: HA Distribution in the Body (includes correspondingGraph/Chart) II-15Properties of HA II-15

4. SEGMENT OVERVIEW II-16Collagen Based Products II-16Urinary Incontinence Implants II-16Classification of Urinary Incontinence II-16Stress Incontinence II-16Urge Incontinence II-16Overflow Incontinence II-16Functional Incontinence II-17Treatment of Urinary Incontinence II-17Periurethral injections (Collagen Injections) II-17Collagen Corneal Shields II-17Research Proceedings II-18Application of Collagen Shields II-18Ocular Surface Lubrication II-18Ocular Surface Protection II-18Drug Delivery II-18Wound Healing II-18Facial Aesthetic Dermal fillers II-18Functions of Collagen-based Facial Implants II-19Aesthetic Dermal fillers - Playing a Major Role II-19Normal Skin Changes Associated with Aging II-19Collagen Injections as Facial implants II-19Wound Dressings II-19Leading Players in the Collagen-based Wound Dressings Market II-20Global Wound Care Market Flaunts Steady Growth II-20Other Applications of Collagen II-21Collagen Gene Delivery Systems II-21Collagen as Bone Graft Substitution II-21Artificial Skin II-21Hyaluronic Acid Based Biomaterials II-21Viscosupplementation II-22Hyaluronic Acid as Viscosupplement II-22Viscosupplementation Treatment for Osteoarthritis II-22Major Hyaluronic Acid Based Viscosupplements II-22Viscoelastics II-23Facial Aesthetic Dermal fillers II-23Commercially Available HA Soft Tissue Fillers II-23Review of Select HA based Aesthetic Dermal Implant Products II-23Advantages of HA Based Products Over Collagen Products II-24Vesicoureteral Reflux Implants II-24Botox - A Competing Biomaterial II-24

5. PRODUCT INTRODUCTIONS/INNOVATIONS II-25Innocoll Completes Phase 2 Studies of XaraColl® II-25Abbott Receives European CE Mark for Healon® EndoCoat OVD II-25Innocoll Obtains EU Approval of CollaGUARD Surgical AdhesionBarrier II-25LSP Bio Introduces SportVis™ and RenehaVis™ II-26Lupin launches Hyalgan in India II-26TiGenix Unveils ChondroMimetic™ II-26TiGenix Develops Collagen Biomaterial for Regenerative Repair II-26Lincoln Pharma Introduces Collagen Bio-Tech Products II-27Healthpoint Launches SANTYL® Ointment for Canadian Market II-27Teijin Pharma Introduces SYNVISC in Japan II-27MiMedx Group Introduces New Paradis Vaso Shield™ Device II-28Lifecore Introduces Corgel™ Biohydrogel II-28

6. RECENT INDUSTRY ACTIVITY II-29Royal DSM Takes Over Kensey Nash II-29Angel Biotechnology Holdings Acquires Specific Assets ofCollagen and Biomaterial Manufacturing Business II-29Innocoll Signs License and Distribution Agreement with InresaArzneimittel and Flynn Pharma II-30ConvaTec Acquires Trio Healthcare International II-30ConvaTec Holdings UK Acquires SureCalm Healthcare Holdings II-30Mölnlycke Health Care US Takes Over Burn and Wound CareDivision of Brennen Medical II-31Systagenix Takes Over O2 Insights II-31Smith & Nephew Takes Over Kalypto Medical II-32Novozymes Starts Supply of Hyaluronic Acid II-32Galderma Acquires Q-Med II-32Fidia Obtains Commercial Rights of Hyalgan from Sanofi US II-33Anika Therapeutics and DePuy Mitek Ink licensing and supplyAgreement II-33Merz Pharmaceutical Acquires BioForm Medical II-33Landec Corporation Takes Over Lifecore Biomedical II-33Anika Therapeutics Takes Over Fidia Advanced Biopolymers II-34Anika Inks Agreement with Visco Technologies II-35Kinetic Concepts Signs Agreement with Wright Medical Group II-35Healthpoint Biotherapeutics Takes Over Regranex Gel II-35Innocoll and Merus Labs Sign License and DistributionAgreement for CollaGUARD II-36SCA Acquires Majority Interest in San Saglik II-36Sanofi Completes Genzyme Buyout II-36Derma Sciences Inks Exclusive Distribution Agreement withMedline Industries II-36Quick- Med Technologies Signs Deal with Biosara Corp II-37Medline Industries Enters into Wound Dressing DistributionAgreement with Quick-Med Licensee II-37BSX Signs Marketing Agreement with BHN II-37Medtronic Acquires Osteotech II-38Landec Completes Acquisition of Lifecore Biomedical II-38Merz Completes Take Overof BioForm Medical II-38

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