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Global Pain Management Devices Industry

5. SELECT PAIN MANAGEMENT DEVICE APPROVALS II-29Myoscience Obtains FDA Approval for New Pain Management Device II-29Nevro Obtains FDA Approval to Start SENZA-RCT Clinical Trial II-29Medasys Obtains PMA Approval from FDA for Prometra® II-29Boston Scientific Obtains CE Mark Approval for Infinion™16Percutaneous Lead II-30Boston Scientific Obtains FDA Approval for Infinion™16Percutaneous Lead II-30Medtronic Receives FDA Approval for New NeurostimulationSystem II-30St. Jude Medical Obtains FDA Approval for EpiducerNeurostimulation Delivery System II-31St. Jude Medical Receives European CE Mark Approval for Penta™Surgical Lead II-31Wellness Pro 2010 ® Micro Current Frequency Generator ReceivesFDA Approval II-31

6. PRODUCT INNOVATIONS/INTRODUCTIONS II-32Bio-Medical Research Introduces Neurotech Recovery Device II-32DJO Global Unveils OA Nano™ Knee Brace II-32Smiths Medical Unveils CADD®-Solis System with PIB II-32DJO Global Introduces Empi Active™ Knee Transcutaneous TENSSystem II-32Boston Scientific Introduces D4 and W4 Spinal Cord StimulationLead Splitters II-33Competitive Technologies Commercially Launches Calmare® II-33

7. RECENT INDUSTRY ACTIVITY II-34Kimberly-Clark Takes Over Pain Management Division of BaylisMedical II-34Competitive Technologies and Calmare® Scrambler Therapy®Extend Agreement II-34Amerinet Signs Agreement with MMJ Labs II-34Meridian Health System Forms Joint Mobile Health Venture withCypak II-34St Jude Medical Inks Agreement with Greatbatch Medical II-35NeuroTherm Acquires Smith & Nephew's Interventional Spine PainManagement Assets II-35

8. FOCUS ON SELECT PLAYERS II-36Boston Scientific Corporation (US) II-36Codman & Shurtleff, Inc. (US) II-36DJO Global, Inc. (US) II-37Kimberly-Clark Corporation (US) II-37Bio-Medical Research (BMR) Ltd. ( Ireland) II-38Medtronic, Inc. (US) II-38NeuroTherm® (US) II-39Smiths Medical (UK) II-39St. Jude Medical, Inc. (US) II-40Stryker Corporation (US) II-41

9. GLOBAL MARKET PERSPECTIVE II-43Table 6: World Recent Past, Current & Future Analysis for PainManagement Devices by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Restof World Markets Independently Analyzed with Annual RevenueFigures in US$ Million for Years 2010 through 2018 (includescorresponding Graph/Chart) II-43

Table 7: World Historic Review for Pain Management Devices byGeographic Region - US, Canada, Japan, Europe, Asia-Pacific(excluding Japan), Latin America and Rest of World MarketsIndependently Analyzed with Annual Revenue Figures in US$Million for Years 2004 through 2009 (includes correspondingGraph/Chart) II-44

Table 8: World 15-Year Perspective for Pain Management Devicesby Geographic Region - Percentage Breakdown of Annual Revenuefor US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets for Years2004, 2012 & 2018 (includes corresponding Graph/Chart) II-45

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