In this clinical study, heroin addicts were randomized into separate treatment groups of placebo, 40 mg/day MN-166 or 80 mg/day MN-166. Safety and tolerability and preliminary efficacy were major analyzed outcomes. Dose-related ibudilast efficacy was also observed in the study. For example, physical withdrawal symptoms were significantly reduced (p≤0.05) by MN-166 treatment as measured by the Subjective Opioid Withdrawal Scale (SOWS) and oxycodone-mediated analgesia (McGill pain questionnaire) was significantly enhanced (p≤0.05) by 80 mg/day ibudilast compared to placebo. Moreover, opioid-related pupil constriction was greater in the 80 mg/day ibudilast group compared to the placebo group (p≤0.05) suggesting lessened tolerance development. Ibudilast was safe and well-tolerated in the study with no serious adverse events, no discontinuations due to treatment and no impact on opioid respiratory changes compared to placebo."We are pleased with the outcome of this study and excited that it was selected for presentation at AAN," commented Dr. Yuichi Iwaki, President and CEO of MediciNova. "We look forward to the next milestone in this indication which will be completion of the ongoing Phase 2a clinical trial of MN-166 in subjects addicted to prescription opioids or heroin."
MediciNova Announces MN-166 (ibudilast) Opioid Withdrawal And Analgesia Data Presentation At The American Academy Of Neurology Annual Meeting
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