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Alexion Joins The International Federation Of Kidney Foundations In Celebrating World Kidney Day 2013

“We know first-hand the importance of the disease awareness efforts taking part on World Kidney Day 2013. In serving patients with aHUS, we are continually reminded of the devastation that kidney damage causes and the importance of disease education to facilitate early diagnosis and timely intervention,” said Stephen P. Squinto, PhD, Executive Vice President and Head of Research and Development of Alexion. "We are pleased to support the International Society of Nephrology and the International Federation of Kidney Foundations in their efforts to help patients with other severe diseases that affect the kidneys.”

In addition to its work in aHUS, Alexion is conducting investigational studies in kidney transplant patients who are at elevated risk for antibody mediated rejection, or other kidney transplant patients who are at elevated risk for delayed graft function.

For more information about World Kidney Day, visit www.worldkidneyday.org.

About aHUS

aHUS is a chronic, ultra-rare, and life-threatening disease in which a genetic deficiency in one or more complement regulatory genes causes chronic uncontrolled complement activation, resulting in complement-mediated thrombotic microangiopathy (TMA), the formation of blood clots in small blood vessels throughout the body. 4,5 Permanent, uncontrolled complement activation in aHUS causes a life-long risk for TMA, which leads to sudden, catastrophic, and life-threatening damage to the kidney, brain, heart, and other vital organs, and premature death. 4,6 Sixty-five percent of all patients with aHUS require kidney dialysis, have permanent kidney damage or die within the first year after diagnosis despite plasma exchange or plasma infusion (PE/PI). 2,3 The majority of patients with aHUS who receive a kidney transplant commonly experience subsequent systemic TMA, resulting in a 90% transplant failure rate in these TMA patients. 7

aHUS affects both children and adults. 8 Complement-mediated TMA also causes reduction in platelet count (thrombocytopenia) and red blood cell destruction (hemolysis). While mutations have been identified in at least ten different complement regulatory genes, mutations are not identified in 30-50% of patients with a confirmed diagnosis of aHUS. 8

About Alexion

Alexion Pharmaceuticals, Inc. is a biopharmaceutical company focused on serving patients with severe and ultra-rare disorders through the innovation, development and commercialization of life-transforming therapeutic products. Alexion is the global leader in complement inhibition and has developed and markets a treatment for patients with PNH and aHUS, two debilitating, ultra-rare and life-threatening disorders caused by chronic uncontrolled complement activation. The treatment is currently approved in more than 40 countries for the treatment of PNH, and in the United States and the European Union for the treatment of aHUS. Alexion is evaluating other potential indications for its marketed drug and is developing four other highly innovative biotechnology product candidates, which are being investigated across nine severe and ultra-rare disorders beyond PNH and aHUS. This press release and further information about Alexion Pharmaceuticals, Inc. can be found at: www.alexionpharma.com.

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