This Day On The Street
Continue to site
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here

Gilead’s Ranexa® Reduces Angina Frequency In Study Of Chronic Angina Patients With Type 2 Diabetes

During weeks 2-8, average weekly angina frequency was significantly lower with ranolazine versus placebo (3.8 [3.6-4.1] versus 4.3 [4.0-4.5] episodes, P=0.008), as was weekly sublingual nitroglycerin use (1.7 [1.6-1.9] versus 2.1 [1.9-2.3] doses, P=0.003).

The rate of serious adverse events and the rate of discontinuations due to adverse events were similar between the ranolazine and placebo groups. Notable non-serious adverse events included nausea, reported in 17 ranolazine and two placebo patients; dizziness, reported in 17 ranolazine and six placebo patients; and constipation, reported in eight ranolazine and two placebo patients; see below for important safety information.

About the TERISA Study

TERISA was a randomized, double-blind, placebo-controlled, parallel study designed to evaluate the efficacy of ranolazine in chronic stable angina patients with concurrent type 2 diabetes who remain symptomatic for angina despite receiving a stable dose of one or two concomitant antianginal agents, including beta-blockers, calcium channel blockers or long-acting nitrates.

A total of 949 patients were randomized (1:1, 473 and 476 in the ranolazine and placebo arms, respectively), 22 of whom either never initiated or discontinued treatment during the first two weeks (11 in each treatment arm), leaving 927 evaluable patients (462 and 465 in the ranolazine and placebo arms, respectively). Their mean age was 64 and 61 percent were male. The patients had a mean diabetes duration of 7.5 years and a mean baseline hemoglobin A1c (HbA1c, a laboratory measure of blood glucose) level of 7.3 percent. At randomization, 56 percent of patients were receiving one antianginal agent and 44 percent were receiving two antianginal agents.

The primary efficacy endpoint was average angina frequency during weeks 2-8, with the effect of ranolazine treatment estimated as a ratio of ranolazine to placebo frequency. During the four-week, single-blind, placebo run-in phase, average weekly angina frequency was similar between the ranolazine and placebo groups (6.6 [6.3-7.0] versus 6.8 [6.4-7.2]; ratio 0.98 [0.91-1.05]). During weeks 2-8, weekly angina frequency was significantly lower in the ranolazine group than in the placebo group (3.8 [3.6-4.1] versus 4.3 [4.0-4.5] episodes; ratio 0.89 [0.82-0.97] P=0.008).

2 of 5

Check Out Our Best Services for Investors

Action Alerts PLUS

Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
Quant Ratings

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
Stocks Under $10

David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
14-Days Free
Only $9.95
14-Days Free
Dividend Stock Advisor

David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks

Every recommendation goes through 3 layers of intense scrutiny—quantitative, fundamental and technical analysis—to maximize profit potential and minimize risk.

Product Features:
  • Model Portfolio
  • Intra Day Trade alerts
  • Access to Quant Ratings
Real Money

More than 30 investing pros with skin in the game give you actionable insight and investment ideas.

Product Features:
  • Access to Jim Cramer's daily blog
  • Intraday commentary and news
  • Real-time trading forums
Only $49.95
14-Days Free
14-Days Free
AAPL $93.24 0.00%
FB $117.81 0.00%
GOOG $701.43 0.00%
TSLA $211.53 0.00%
YHOO $36.94 0.00%


Chart of I:DJI
DOW 17,660.71 +9.45 0.05%
S&P 500 2,050.63 -0.49 -0.02%
NASDAQ 4,717.0940 -8.5450 -0.18%

Free Reports

Top Rated Stocks Top Rated Funds Top Rated ETFs