SALT LAKE CITY, March 5, 2013 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (Nasdaq:MYGN) announced today that a study published in the Journal of Clinical Oncology demonstrated that its Prolaris test, which analyzes the expression level of 46 cell cycle progression genes, accurately predicted the elevated risk for prostate cancer recurrence in 413 men who had undergone a radical prostatectomy. The study entitled "Validation of a panel of cell cycle progression genes for improved risk-stratification in a contemporary radical prostatectomy cohort," concluded that the Prolaris test effectively stratified men by risk of biochemical recurrence.
Researchers at the University of California, San Francisco, and Myriad Genetics, found that 100% of patients in the study with low-risk Prolaris scores did not have any recurrence of their prostate cancer within the five year study period. However, prostate cancer did recur in 50% of the patients in the study with high-risk Prolaris scores. Importantly, the Prolaris test was found to more accurately predict the risk of prostate cancer recurrence than current clinical parameters used in risk assessment. The authors concluded that the findings may help healthcare providers make better informed decisions regarding treatment of patients following radical prostatectomy.
Following the publication of this study in JCO, Prolaris will have published, peer reviewed data incorporating four major studies and over 1,500 patients. In all four studies, researchers were able to demonstrate the effectiveness of the Prolaris test as a prognostic tool for predicting the risk of recurrence and prostate cancer survival across a variety of tissue formats. Survival and disease recurrence are the gold standard end points for cancer clinical trials and provide the physicians with actionable information that may guide treatment decisions."Myriad's Prolaris test is the only test on the market that has consistently demonstrated prognostic value in both pre and post prostatectomy settings," said Jerry Lanchbury Ph.D., Chief Scientific Officer of Myriad Genetics Inc. "The Prolaris test provides physicians and patients with a better risk assessment tool to predict which men are more likely to have recurrence of their disease even after undergoing aggressive treatment such as a radical prostatectomy."
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