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(Video: Business Wire)

BioTime, Inc. (NYSE MKT: BTX) and its bioinformatics subsidiary LifeMap Sciences, Inc. (“LifeMap”) today announced that they have entered into a definitive collaboration agreement to utilize LifeMap’s computer-based tools to extract information relating to novel potential commercial products from nearly 100 million proprietary gene expression data points generated and owned by BioTime. The assembled data relate to BioTime’s proprietary PureStem™ progenitor cell lines derived from human embryonic stem cells. The two companies will share revenues resulting from commercialization of successful product candidates that are discovered via the collaboration. BioTime has the right of first refusal to advance, either directly or via any of its other subsidiaries, selected products under a milestones and royalty arrangement with LifeMap. LifeMap will have an exclusive option to advance those products that BioTime chooses not to pursue itself or via its other subsidiaries.

Background

Human pluripotent stem cells such as human embryonic stem (hES) and induced pluripotent stem (iPS) cells have the important distinction of being the first human cells ever discovered that are capable of indefinite scale-up in the stem cell state, with the potential to then become any of the thousands of different cell types that make up the human body. The discovery of hES cells in the late 1990s led to the emerging field called regenerative medicine. BioTime’s mission is to lead in the commercial application of pluripotent stem cell technology in regenerative medicine by utilizing a number of novel cell manufacturing platforms such as PureStem™ human progenitor cell lines. These hES- or iPS-derived cell lines are relatively pure and scalable lines of cells that allow the industrial scale-up of sufficiently large numbers of cells to be potentially useful in treating a wide array of degenerative diseases including those afflicting an aging population.

BioTime scientists have performed thousands of differentiation protocols with these novel PureStem™ cell lines using a technology called “fate space screening”. A video describing the novel technology is now available for viewing at www.biotimeinc.com/corporate-videos/. This large amount of accumulated data provides deep insights into the molecular processes involved in human development and advances our understanding of how to utilize the cells clinically to regenerate tissues afflicted with disease. While a limited amount of this data has been published, the majority of the intellectual property is proprietary to BioTime and will be shared with LifeMap under the new agreement.

Under the collaboration, BioTime and LifeMap scientists will work closely together to extract from the approximately 100 million proprietary gene expression data points information expected to lead to new patent applications for cell-based regenerative therapies. Examples of cellular therapies needed in medicine include those for the repair of cartilage, bone, tendon, heart muscle, the vascular system, the retina, and many others. A brief overview of the proprietary discovery process invented by LifeMap scientists is shown as part of the video that describes the fate space screening, which can also be found at www.lifemapsc.com/TherapeuticDiscovery.

The PureStem TM cell lines are a diverse library of purified cell lines representing young cells intermediate in their differentiation between the hES cells and the final, mature cells. Each PureStem™ cell line has a unique gene expression “signature”. This signature is altered in novel ways when a PureStem™ cell line is exposed to different experimental conditions utilizing protein growth and differentiation factors.

The LifeMap Discovery™ platform provides the road map that enables “navigating” each of the PureStem™ cell lines to the desired “destination” of a certain mature cell type for use in treatment. It includes reference gene expression signatures of thousands of embryonic and mature cell types. LifeMap’s scientists match the signatures of PureStem™ cell lines to the cells in its database using tailored bioinformatics computer tools and determine the identity of PureStem™ cell lines before and after they are exposed to various growth and differentiation conditions. In the next step, PureStem™ cell lines that may potentially replace, or rejuvenate, diseased tissues can be identified and later tested for their therapeutic potential for selected diseases.

Recently, BioTime and LifeMap Sciences, along with another BioTime subsidiary, OrthoCyte Corporation, reported in the peer-reviewed journal  Regenerative Medicine a means of manufacturing distinct types of cartilage, bone, and tendon cells from seven of BioTime’s proprietary  PureStem TM human embryonic progenitor cell lines, with potential applications for the repair of different types of bone, cartilage, and tendon for the treatment of degenerative diseases afflicting these tissue types such as non-healing bone fractures, osteoarthritis and degeneration of intervertebral discs, and tendon tears. The data mining collaboration is expected to yield many additional PureStem™ cell lines with various clinical applications for the treatment of degenerative diseases.

“LifeMap Sciences, through its online databases such as GeneCards ®, MalaCards, and LifeMap Discovery™, as well as its internal research team, has assembled one of the world’s most powerful molecular analysis capabilities,” said Michael West, PhD, CEO of BioTime and Chief Scientific Officer of LifeMap. “We have already filed for patent protection on inventions jointly made by the teams and look forward to accelerating the pace of development of cures for the deadly degenerative diseases of aging.”

“The BioTime and LifeMap teams collectively believe that this collaboration has the potential to generate a robust pipeline of important stem-cell-based treatments for commonly occurring degenerative diseases,” said David Warshawsky, PhD, President and CEO of LifeMap. “However, it would take the emergence of only a single significant treatment from this collaboration to make this a seminal event for both companies.”

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