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Epigenetic Therapies And Technologies: World Market Prospects 2013-2023

8.2 Present and Future Epigenetic Research in Cancer

8.2.1 Twin Studies Reveal Epigenetic Biomarkers in Breast Cancer

8.2.2 Colorectal Cancer: Beyond Two Well-Established Biomarkers

8.2.3 Prognostic Markers in Lung Cancer

8.2.4 Prostate Cancer: Advances in Diagnostics, but Little Progress in Epigenetic Therapies

8.3 DNA Hypomethylation in Autoimmune Diseases

8.3.1 Lupus

8.3.2 Rheumatoid Arthritis as a Target for Drug and Diagnostic Development

8.3.2.1 Case Study: Ignyta, Pioneering Epigenetic Diagnostics in Rheumatoid Arthritis

8.3.3 Diabetes Incidence is Linked to Ageing and Diet

8.4 Neurodegenerative Diseases

8.4.1 Alzheimer's Disease: Alleviation of Symptoms Using HDAC Inhibitors

8.4.2 Huntington's Disease: Epigenetic Drugs Approaching Clinical Development

8.5 Neurological Disorders

8.5.1 Drug Resistance in Schizophrenia

8.5.2 Autism is Linked to Many Genetic and Epigenetic Mutations

8.6 New Epigenetic Drug Targets

8.6.1 BET Proteins Are a Target in Many Therapeutic Areas

8.6.2 Assessing and Understanding DNA Hydroxymethylation

8.6.3 Sirtuins as an Underexploited HDAC Inhibitor Class

8.6.4 Histone Methyltransferase

8.6.4.1 Lysine Methyltransferase

8.6.4.2 Case Study: Domainex Developing HMT Inhibitors

8.6.4.3 Protein Arginine Methyltransferases: Overcoming Insufficient Potency

8.6.5 Lysine Demethylases Show Promise as Targets for Cancer Therapies

9. Epigenetic Therapies and Technologies: Industry Trends 2013-2023

9.1 Epigenetic Therapies and Technologies Market: Strengths and Weaknesses 2011-20129.1.1 Understanding Epigenetic Markers and Mechanisms9.1.2 Specificity of Current Epigenetic Therapies9.2 Epigenetic Therapies and Technologies Market: Opportunities and Threats 2013-20239.2.1 The Importance of Translational Research9.2.2 Developing Companion Diagnostics9.2.3 Long Therapeutic and Diagnostic Pipelines9.2.4 Combination Therapy with Epigenetic Drugs9.2.5 Epigenetic Therapies to Overcome Drug Resistance9.2.6 Drug Targets Beyond HDAC and DNMT Inhibition9.3 Epigenetic Therapies and Technologies: STEP Analysis 2013-20239.4 Social Factors Influencing Product Development9.4.1 Epigenetics and the Environment9.4.2 Epigenetics, Ageing, and Disease9.4.2.1 Rising Global Disease Incidence to Drive Epigenetics Market Growth9.4.3 Targeting Orphan Indications and Patient Subpopulations9.4.4 Epigenetics Can Lead to Personalised and Stratified Medicine9.5 Technological Developments to Aid Epigenetic Research9.5.1 Next-Generation Sequencing Improving Epigenetic Research9.5.2 Using Epigenetics to Drive Forward Stem Cell Research9.5.3 Complementary and Competing Technologies9.5.3.1 Genomics9.5.3.2 Proteomics9.5.3.3 Metabolomics: A Comparatively New Discipline9.6 Economic Factors9.6.1 The Cost of Epigenetic Research9.6.2 The Role of Big Pharma in the Epigenetics Market 2013-20239.6.2.1 Pfizer9.6.2.2 Novartis: Performing Epigenetic Research in China9.6.2.3 GSK Has Signed Many Deals in Epigenetics9.6.3 Major Licensing Deals in Epigenetics9.6.4 Epigenetic Business Models9.7 Political Issues9.7.1 Ethics in Epigenetic Research9.7.2 Collaboration in Epigenetic Research9.7.2.1 Structural Genomics Consortium9.7.2.2 NIH Roadmap Epigenetics Project9.7.2.3 International Human Epigenome Consortium9.7.2.4 Blueprint: Contributing to Global Epigenome Libraries

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