ND0612 is a proprietary formulation of levodopa and carbidopa administered through a pump patch that enables, for the first time, to conveniently achieve steady state levodopa plasma levels. Levodopa and carbidopa (traditionally co-administered with levodopa to prevent its breakdown) are nearly always administered orally and suffer from an unfavorable pharmacokinetic profile due to short half life and low bioavailability. Continuous subcutaneous delivery of levodopa and carbidopa is a novel approach designed to improve their pharmacokinetic profile and maintain stable, therapeutic levodopa plasma concentrations, thereby significantly ameliorating motor fluctuations and non-motor complications in Parkinson's disease.
NeuroDerm is an emerging pharmaceutical company that develops therapies for the treatment of CNS diseases. NeuroDerm's technology is based on proprietary reformulations of well established oral drugs whose low bio-availability is the major impediment to better efficacy. The company's lead products are ND0612 and ND0611, revolutionary SC drugs for the treatment of Parkinson's disease and ND0801, a combination patch for the treatment of ADD/ADHD. Other programs focused at other diseases, including schizophrenia and Alzheimer's disease, are in different stages of development. NeuroDerm is headquartered in the Weizmann Science Park, Ness Ziona, Israel.Contact: Oded S. Lieberman, PhD MBA, Chairman & CEO firstname.lastname@example.org Tel.: +972-8-946-2729 Cell: +1-617-517-6077 3 Golda Meir St Weizmann Park P.O. Box 4150 Ness Ziona 74140, ISRAEL Tel. +972-8-9462729 Fax. +972-8-9461729 SOURCE NeuroDerm Ltd