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NEW YORK, Feb. 28, 2013 (GLOBE NEWSWIRE) -- Intellect Neurosciences, Inc. (OTCBB:ILNS) announces Dr. Daniel G. Chain, Chairman and CEO, will present at the Bio-Europe Spring Conference March 11-13, 2012 at the Centre Convencions Internacional in Barcelona, Spain.
Dr. Chain's presentation, which begins at 10:00 am local time on March 12
th, features the company's CONJUMAB platform technology, including its lead compound, CONJUMAB-A, an antibody drug conjugate being developed for age-related macular degeneration (AMD) as well as the company's tau antibody technology. Dr. Chain will also be attending the 11
th Annual Conference on Alzheimer's disease and Parkinson's disease from March 6-10 in Florence, Italy.
"We discovered a novel way to attack certain types of complex diseases through the use of antibody drug conjugates (ADCs) in which two different molecules - an antibody targeting an amyloidogenic polypeptide and a small neuroprotective molecule - are combined chemically into a single entity," said Dr. Daniel Chain, the inventor of CONJUMAB. "The antibody has a chaperone-like role in clearing the amyloid while the small molecule reduces the neurotoxicity caused by the peptide. Our lead drug candidate CONJUMAB-A, capitalizes on recent insights linking the mechanisms that contribute to the pathogenesis of AMD and Alzheimer's disease, especially the role of oxidative stress and amyloid beta (Aβ) which is believed to be an essential mediator in the progression of dry AMD to wet AMD."
Traditionally, ADCs have been used to deliver a cytotoxic payload to kill cancer cells. By contrast, drugs based on CONJUMAB are comprised of antibodies targeting amyloidogenic polypeptides that would be linked chemically to a small molecule that is non-toxic and instead confers cytoprotective properties such as an antioxidant or anti-inflammatory molecule. CONJUMAB-A is comprised of a humanized monoclonal antibody against beta amyloid (Aβ) conjugated to melatonin, a potent antioxidant molecule with anti-amyloidogenic, anti-inflammatory and anti-apoptotic properties with the aim of preventing the accumulation of toxic Aβ in the retina and delivering on-site neuroprotection to reduce geographical atrophy and neovascularization.