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Abnormal Growth Regulation May Occur In Children With Heart Defects

-- CHOP Cardiology Researchers Analyze Poor Growth in Children with Congenital Heart Disease--

PHILADELPHIA, Feb. 19, 2013 /PRNewswire-USNewswire/ -- The poor growth seen in children born with complex heart defects may result from factors beyond deficient nutrition. A new study by pediatric researchers suggests that abnormalities in overall growth regulation play a role.

"When compared with their healthy peers, children with congenital heart disease have impaired growth, as measured in weight, length, and head circumference," said senior author Meryl S. Cohen, M.D., a pediatric cardiologist in the Cardiac Center at The Children's Hospital of Philadelphia. "We investigated patterns of poor growth in these children, as a starting point in guiding us toward more effective treatments." 

The study appeared as an online article in the January 2013 issue of Pediatrics.

The researchers performed a retrospective analysis of medical records of 856 children with congenital heart disease (CHD), compared to 7,654 matched control subjects. All the children were measured up to age 3, and all were drawn from the healthcare network of The Children's Hospital of Philadelphia.

Within weeks of birth, the children with CHD had significant deficits in weight, length and head circumference, compared to matched controls without CHD. The largest differences in weight occurred at 4 months of age. Among the 856 children with CHD, the 248 who required surgical repair were much more likely to be below the 3 rd percentile in weight, length and head circumference during early infancy, and their growth by age 3 did not catch up with that of their healthy peers.

In the 608 children with CHD who did not require surgery, growth differences were not as pronounced, but even their growth patterns lagged behind those of healthy controls.

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