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Shire's VPRIV® Wins First Ever "Novel Treatment Award" From Lysosomal Disease Network At Their 9th WORLD Symposium

LEXINGTON, Massachusetts, February 19, 2013 /PRNewswire/ --

Shire plc (LSE: SHP, NASDAQ: SHPG), announces that the Lysosomal Disease Network (LDN) presented Shire Human Genetic Therapies (HGT) with the first ever Novel Treatment Award for VPRIV on February 14 th, at its 9th Annual WORLD Symposium. The LDN have launched this new award, which will be presented annually, to recognize new drugs or therapies that have made a considerable contribution in the area of lysosomal diseases.

"Shire has demonstrated its commitment to developing new therapies for the treatment of rare genetic diseases. We wanted to recognize the contribution of VPRIV for the treatment of type 1 Gaucher disease by awarding Shire the first ever Novel Treatment Award," said Chester Whitley, University of Minnesota and Principal Investigator, LDN. "As new treatments are developed, we want to be sure that these huge efforts and accomplishments are recognized in the hope of inspiring other young investigators and corporate developers. We hope that this award is a way of demonstrating this."

VPRIV is an enzyme replacement therapy (ERT) used for the long-term treatment of patients with type 1 Gaucher disease. The safety and efficacy of VPRIV was assessed in more than 100 patients at 24 sites in 10 countries, representing the largest and most comprehensive clinical data set to support registration for an ERT for type 1 Gaucher disease. VPRIV is manufactured using a human cell line with Shire's proprietary gene activation technology.

"As a leader in rare diseases, Shire is honored to be recognized by LDN with its first Novel Treatment Award," said Dr. Philip J. Vickers, Global Head of Research and Development, Shire HGT. "This award embodies the spirit of our organization - every employee at Shire is dedicated to developing and bringing forward new products, services and support offerings which can make a positive impact on patients' lives. Shire is proud to provide Gaucher patients with an effective treatment option and continues to build upon a solid foundation, established by our lysosomal enzyme replacement therapies, to further support rare disease patients around the world."

As part of its ongoing commitment in type 1 Gaucher disease, Shire continues to invest in further evaluating the safety and efficacy of VPRIV through the generation of long-term clinical trial data, additional pediatric data, as well as the long-term observational data collected through the Gaucher Outcomes Survey.  

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