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Intraocular Lens (IOL): Market Shares, Strategies, And Forecasts, Worldwide, Nanotechnology, 2013 To 2018

Table of Contents

INTRAOCULAR LENS (IOL) - EXECUTIVE SUMMARY ES-1

Intraocular Lens Market Driving Forces ES-1 Cataract Surgical Technology Is Evolving Rapidly ES-3 Patient Populations Have Significant Demand for Cataract Surgery ES-4 Challenge To Get Wide Acceptance Of A New Lens Once It Is Approved ES-5 Cataract Surgery Business ES-5 Intraocular Lens Market Challenges ES-6 World Population Growth ES-6 Intraocular Lens Market Shares ES-7 Intraocular Lens Market Forecasts ES-9

1. INTRAOCULAR LENS - MARKET DESCRIPTION AND MARKET DYNAMICS 1-1

1.1 Cataract Surgical Technology Is Evolving Rapidly 1-1 1.1.1 Patient Populations Have Significant Demand for Cataract Surgery 1-2 1.1.2 Challenge To Get Wide Acceptance Of A New Lens Once It Is Approved 1-4 1.1.3 Cataract Surgery Business 1-4 1.1.4 Intraocular Lens Market Challenges 1-6 1.2 World Economy Undergoing A Transformation 1-7 1.2.1 Global Economic Conditions: 1-7 1.2.2 Global Economy Becomes Steadily More Sluggish 1-9 1.2.3 Global Economic Conditions Impact Markets 1-11

2. INTRAOCULAR LENS - MARKET SHARES AND FORECASTS 2-1

2.1 Intraocular Lens Market Driving Forces 2-1 2.1.1 Cataract Surgical Technology Is Evolving Rapidly 2-3 2.1.2 Patient Populations Have Significant Demand for Cataract Surgery 2-4 2.1.3 Challenge To Get Wide Acceptance Of A New Lens Once It Is Approved 2-5 2.1.4 Cataract Surgery Business 2-5 2.1.5 Intraocular Lens Market Challenges 2-6 2.1.6 World Population Growth 2-6 2.2 Intraocular Lens Market Shares 2-7 2.2.1 Novartis / Alcon 2-10 2.2.2 Novartis / Alcon Competitive Situation 2-10 2.2.3 Novartis / Alcon Competition 2-10 2.2.4 Novartis Alcon Multifocal Lenses 2-11 2.2.5 Novartis / Alcon 2-12 2.2.6 Novartis / Alcon 2-13 2.2.7 Novartis / Alcon AcrySof Toric Intraocular Lens - (IOL) – FDA Approval P930014/S045 2-13 2.2.8 LenSx Acquired by Alcon 2-16 2.2.9 Abbott Medical Optics 2-17 2.2.10 Abbott Medical Optics / Visiogen's Synchrony 2-17 2.2.11 Abbott Tecnis 2-18 2.2.12 Abbott TECNIS IOLs 2-18 2.2.13 Bausch & Lomb Presbyopic IOLs 2-19 2.2.14 Bausch + Lomb 2-19 2.2.15 Bausch + Lomb Eye Surgical Technologies In The Pipeline 2-20 2.2.16 Bausch + Lomb: Accommodating IOLs 2-21 2.2.17 Bausch + Lomb: Crystalens IOL 2-22 2.2.18 OptiMedica 2-22 2.2.19 Staar Acrylic IOL 2-23 2.2.20 Staar 2-23 2.2.21 Staar Silicone IOLs 2-24 2.2.22 Staar Surgical Company nanoFLEX IOL 2-24 2.2.23 Staar Visian 2-25 2.2.24 LensAR 2-25 2.2.25 PhysIOL's FineVision 2-26 2.2.26 IOL Research and New Lenses 2-26 2.2.27 ReSTOR Multifocal Toric AcrySof IQ 2-27 2.2.28 Abbott Tecnis One-Piece Toric 2-29 2.2.29 Lenstec Tetraflex 2-29 2.2.30 Calhoun Vision Light-Adjustable Lens 2-30 2.2.31 Abbott Visiogen Synchrony 2-31 2.2.32 Rayner M-flex T 2-32 2.2.33 NuLens DynaCurv 2-33 2.2.34 Carl Zeiss AcriLisa Diffractive Multifocal Toric 2-33 2.2.35 Bausch + Lomb's Crystalens Toric 2-34 2.2.36 Hoya's Adoptics 2-34 2.3 Intraocular Lens Market Forecasts 2-35 2.3.1 Intraocular Lens Market Segment Forecasts 2-37 2.3.2 Number of Cataract Surgeries Per Year 2-40 2.3.3 Novartis Positioning with Sales and Marketing Resource 2-42 2.3.4 Bausch + Lomb Small Incisions 2-44 2.3.5 Femtosecond Technology Is Game Changer 2-44 2.3.6 Intraocular Lens Unit Analysis 2-46 2.3.7 Aspheric Foldable IOL Lens 2-46 2.3.8 Intraocular Lens Presbyopia Market Forecasts 2-48 2.3.9 Market Trend: Monofocal IOL Channel Will Be Slowly But Continuously Eroded By The Multifocal IOL 2-49 2.3.10 Presbyopia-Correcting Intraocular Lens (IOL) 2-49 2.3.11 Premium Channel Surgeons 2-49 2.3.12 Market Trend: Accommodating IOL Channel to Grow 2-51 2.3.13 Market Trends: Diffractive Lenses 2-52 2.3.14 Market Trend: Multifocal IOLs 2-52 2.3.15 Market Trend: Surgical Workstation 2-53 2.3.16 Premium IOL Forecasts 2-53 2.3.17 Technologies Driving Intraocular Lens IOL Market Growth 2-54 2.3.18 Diffractive IOLs 2-55 2.3.19 Large Middleclass Population Base Driving Intraocular Lens IOL Market Growth 2-55 2.3.20 Nonfoldable Polymethylmethacrylate/Plexiglas Based Lenses To Silicone And Acrylic Based Foldable Lenses 2-56 2.3.21 Global Vision Care and Ocular Market 2-56 2.4 Intraocular Lens Prices 2-57 2.4.1 Premium Lens Technology Reimbursement Trends 2-57 2.4.2 CMS Medicare Intorocular Reimbursement Guidelines 2-57 2.5 Intraocular Lens Regional Market 2-58 2.5.1 Eye Surgical Techniques by Country 2-62 2.5.2 United States 2-65 2.5.3 Canada 2-65 2.5.4 Brazil Cataract Surgical Procedure 2-67 2.5.5 Brazilian Cataract surgeries 2-68 2.5.6 China 2-68 2.5.7 Toric Lens Implantations On The Rise In Europe 2-68 2.5.8 Advanced Technology Intraocular Lens Growth Markets 2-69 2.5.9 Cataract Surgery in the UK 2-70 2.5.10 Asia-Pacific Cataract Surgery 2-70 2.5.11 Cataract Surgery in India 2-71 2.5.12 Cataract Surgery Assembly Line System Followed At Aravind Eye Hospitals 2-73 2.5.13 Aurolab's Low-Cost, High-Volume Business Model 2-74 2.5.14 Highly Efficient Operations Coupled With Pricing Structure Allow 50% Profit Margin 2-74 2.5.15 World Health Organization (WHO), 2-75

3. INTRAOCULAR LENS (IOL) - PRODUCT DESCRIPTION 3-1

3.1 IOL lenses 3-1 3.2 Novartis / Alcon 3-2 2.1.1 Novartis / Alcon 3-2 2.1.2 Novartis / Alcon Competitive Situation 3-3 2.1.3 Novartis / Alcon Competition 3-3 2.1.4 Novartis Alcon Multifocal Lenses 3-4 2.1.5 Novartis / Alcon 3-5 2.1.6 Novartis / Alcon 3-6 2.1.7 Novartis / Alcon AcrySof Toric Intraocular Lens - (IOL) – FDA Approval P930014/S045 3-6 2.1.8 LenSx Acquired by Alcon 3-8 3.3 Abbott Medical Optics / Visiogen's Synchrony 3-9 3.3.1 Abbott Medical Optics Synchrony 3-11 3.3.2 Abbott Medical Optics' 3-12 3.3.3 Abbott Medical Optics / Visiogen's Synchrony Lens 3-12 3.4 Bausch & Lomb / Crystalens 3-17 3.4.1 Bausch & Lomb Crystalens AO Lens 3-18 3.4.2 Bausch + Lomb: Accommodating IOLs 3-18 3.4.3 Bausch + Lomb: Crystalens IOL 3-19 3.4.4 Bausch & Lomb Crystalens HD 3-22 3.5 Calhoun Vision's Light Adjustable Lens 3-23 3.6 NuLens 3-23 3.7 PixelOptics 3-23 3.8 Imperial Medical Technologies' 3-23 3.9 Presbia's Flexivue 3-23 3.10 Lenstec's Tetraflex Lens 3-23 3.11 Staar 3-24 3.11.1 STAAR Surgical Company nanoFLEX IOL 3-25 3.11.2 Staar Elastimide Silicone Aspheric IOL 3-29 3.11.3 Staar nanoFLEX Collamer Aspheric Single-Piece IOL 3-29 3.11.4 Staar Afinity Collamer Aspheric IOL 3-29 3.11.5 STAAR Toric IOL 3-30 3.11.6 Staar Afinity and nanoFLEX Collamer Aspheric IOLs 3-32 3.11.7 Staar Collamer Advantage 3-32 3.11.8 Staar nanoFLEX Collamer Aspheric Single-Piece IOL 3-36 3.11.9 STAAR Surgical Elastimide Silicone Aspheric IOL Model AQ2015A 3-37 3.11.10 STAAR Elastimide Lens Model AQ2003V 3-40 3.11.11 STAAR Elastimide Lens Model AQ2010V 3-41 3.11.12 STAAR Elastimide Lens Model AQ5010V - Low Diopter 3-42 3.11.13 STAAR Elastimide Lens Model AQ2017V (Discontinued) 3-44 3.11.14 STAAR Elastimide Lens Model AQ1016V (Discontinued) 3-45 3.11.15 STAAR Elastic Lens Model AA4204VF 3-46 3.11.16 STAAR Elastic Lens Model AA4204VL 3-47 3.11.17 STAAR Elastic Lens Model AA4207VF (Discontinued) 3-48 3.11.18 STAAR Toric Silicone Single Piece IOL 3-49 3.11.19 STAAR Elastic Toric Lens Model AA4203TL 3-56 3.11.20 Canon-STAAR Preloaded IOL Model KS-3Ai 3-57 3.12 Lxenstec's Tetraflex 3-58 3.12.1 Lxenstec's Tetraflex Manufactured To A Tenth Of A Diopter Toleranc3-e 59 3.12.2 Lxenstec Elenza Lens 3-60 3.13 Hoya 3-60 3.14 Tecnis MF 3-62 3.14.1 PowerVision ( Belmont, Calif.), Oculentis ( Berlin), and PhysIOL (Liège, Belgium 63 3.14.2 PowerVision's FluidVision 3-63 3.14.3 FluidVision 3-64 3.15 MPlus by Oculentis 3-64 3.16 PhysIOL's FineVision 3-65 3.17 WaveTec Vision 3-66 3.18 Pediatric Cataract / Intraocular Lenses (IOL) 3-66 3.18.1 4 D change in power is needed between ages 10 and 20 3-69 3.18.2 Correcting Astigmatism in Pediatric Patients 3-69

4. INTRAOCULAR LENS (IOL) - TECHNOLOGY 4-1

4.1 The Human Eye 4-1 4.2 Cataracts 4-3 4.2.1 Staar Collamer 4-4 4.2.2 Cataract Symptoms 4-17 4.2.3 Benefits Of Cataract Eye Surgery 4-18 4.2.4 How Cataract Eye Surgery Is Performed 4-19 4.3 Intraocular Tens Technology 4-20 4.3.1 Technologies Driving Intraocular Lens IOL Market Growth 4-21 4.4 Aspheric Contact Lenses 4-21 4.5 Refractive Disorders 4-22 4.6 Studies On The Restor Toric Lens 4-22 4.6.1 MNRead Functional Reading Test 4-23 4.7 Surgeons Need To Concentrate On Proper Patient Selection 4-24 4.8 Mayo Clinic Study of Long-Term Dislocation Of Intraocular Lenses 4-24 4.8.1 Obesity Cause of Diabetes and Neuropathy of the Eye 4-25

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