Piromelatine is thought to work through a combination of MT1\MT2 (potential sleep promoting and chronobiotic effects) and 5HT1A\D (potential anxiolytic and analgesic effects) receptors agonism. All potential effects of piromelatine were demonstrated in relevant animal models. Phase-IA and IB studies of safety, tolerability, pharmacokinetics and sleep promoting activity of piromelatine demonstrated dose proportionality PK profile, good absorption and distribution, good safety & tolerability profile across a wide dose range and provided the first indication for a pharmacodynamic activity of Piromelatine on sleep maintenance with no detrimental effects on memory.
About Neurim Pharmaceuticals:
Neurim Pharmaceuticals Ltd., founded in 1991 is a drug discovery and development company focused on the central nervous system (CNS). It's first approved drug, Circadin® - prolonged release melatonin for insomnia is commercially available in more than 40 countries around the world.
For more information: Eran Schenker , MD Medical & Corporate Business Development Director Neurim Pharmaceuticals Ltd. 27 Habarzel St Tel-Aviv 69710 Israel Tel: +972-3-7684914 Cell: +972-52-6689944 EranS@Neurim.comSOURCE Neurim Pharmaceuticals