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Follow-up Data Show ZYTIGA® Plus Prednisone Continues To Delay Progression Of Metastatic Castration-Resistant Prostate Cancer In Patients Without Prior Chemotherapy

Drug Interactions - ZYTIGA ® is an inhibitor of the hepatic drug-metabolizing enzyme CYP2D6.  Avoid co-administration with CYP2D6 substrates that have a narrow therapeutic index.  If an alternative cannot be used, exercise caution and consider a dose reduction of the CYP2D6 substrate.   In vitro, ZYTIGA ® inhibits CYP2C8.  There are no clinical data on its use with drugs that are substrates of CYP2C8. Patients should be monitored closely for signs of toxicity related to the CYP2C8 substrate if used concomitantly with abiraterone acetate.

Based on in vitro data, ZYTIGA ® is a substrate of CYP3A4.  The effects of strong CYP3A4 inhibitors or inducers on the pharmacokinetics of abiraterone have not been evaluated, in vivo.  Strong inhibitors and inducers of CYP3A4 should be avoided or used with caution during treatment with ZYTIGA ®.

Use in Specific Populations - Do not use ZYTIGA ® in patients with baseline severe hepatic impairment (Child-Pugh Class C).

About Janssen Research & Development Janssen Research & Development is headquartered in Raritan, N.J. and has affiliated facilities in Europe, the United States and Asia.  Janssen Research & Development is leveraging a combination of internal and external innovation to discover and develop novel medicines and solutions in five distinct therapeutic areas: Neuroscience, Oncology, Immunology, Infectious Diseases and Vaccines, and Cardiovascular and Metabolism.  For more information about Janssen Research & Development visit www.janssenrnd.com.

Note: Data in this release correspond to ASCO GU Abstract #5.

SOURCE Janssen Research & Development, LLC

Copyright 2011 PR Newswire. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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