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Plunkett's Biotech & Genetics Industry Almanac 2013: Biotech & Genetics Industry Market Research, Statistics, Trends & Leading Companies

14) Domestic & Foreign Pharmaceutical Sales, PhRMA Member Companies: 1975-2011

15) Sales By Geographic Area, PhRMA Member Companies: 2010

16) Domestic U.S. Biopharmaceutical R&D Breakdown, PhRMA Member Companies: 2010

17) Domestic Biopharmaceutical R&D Scientific, Professional & Technical Personnel by Function, PhRMA Member Companies: 2010

18) Domestic U.S. Biopharmaceutical R&D & R&D Abroad, PhRMA Member Companies: 1975-2011

Table of Contents

PLUNKETT'S BIOTECH & GENETICSINDUSTRY ALMANAC 2013CONTENTSA Short Biotech & Genetics Industry Glossary xIntroduction 1How to Use This Book 3Chapter 1: Major Trends Affecting the Biotech & Genetics Industry 71) The State of the Biotechnology Industry Today 82) A Short History of Biotechnology 133) Ethanol Production Soars, But U.S. Federal Subsidy in Question 144) Major Drug Companies Bet on Partnerships With Smaller Biotech Research Firms 175) From India to Singapore to China, Nations Compete Fiercely in Biotech Development 186) Clinical Trials and Medical Records Processing Conducted Abroad Spark Concerns 207) Gene Therapies and Patients' Genetic Profiles Promise a Personalized Approach toMedicine 218) Breakthrough Drugs for Cancer Treatment—Many More Will Follow 249) Few New Blockbusters: Major Drug Patents Expire While Generic Sales Growth Continues 2510) Biotech and Orphan Drugs Pick Up the Slack as Blockbuster Mainstream Drugs Age 2711) Biosimilars (Generic Biotech Drugs) Receive FDA Guidelines for Accelerated Approval/Competition Will Be Fierce 2812) Breakthrough New Drug Delivery Systems Evolve 3013) Stem Cells—Multiple Sources Stem from New Technologies 3014) Government Support for Stem Cell Research Evolves 3215) Stem Cells—Therapeutic Cloning Techniques Advance 3316) Stem Cells—A New Era of Regenerative Medicine Takes Shape 3517) Nanotechnology Converges with Biotech 3718) Agricultural Biotechnology Scores Breakthroughs but Causes Controversy/SelectiveBreeding Offers a Compromise 3819) Focus on Vaccines 4120) Technology Discussion—Genomics 4221) Technology Discussion—Proteomics 4222) Technology Discussion—Microarrays 4323) Technology Discussion—DNA Chips 4324) Technology Discussion—SNPs ("Snips") 4425) Technology Discussion—Combinatorial Chemistry 4426) Technology Discussion—Synthetic Biology 4427) Technology Discussion—Recombinant DNA 4528) Technology Discussion—Polymerase Chain Reaction (PCR) 45Chapter 2: Biotech & Genetics Industry Statistics 46Biotech Industry Overview 47The U.S. Drug Discovery & Approval Process 48U.S. FDA New Drug (NDA) and Biologic (BLA) Approvals, 2011 49U.S. Pharmaceutical R&D Spending Versus the Number of New Molecular Entity (NME)Approvals:1993-2011 50Employment in Life & Physical Science Occupations, U.S.: May 2011 51Federal R&D & R&D Plant Funding for General Science & Basic Research, U.S.:Fiscal Years 2011-2013 52U.S. Exports & Imports of Pharmaceutical Products: 2007-1st Quarter 2012 53U.S. Prescription Drug Expenditures, Aggregate & Per Capita Amounts, Percent Distribution:2006-2021 54U.S. Prescription Drug Expenditures: 1970-2021 56Total U.S. Biotechnology Patents Granted per Year by Patent Class: 1977-2011 58Research Funding for Biological Sciences, U.S. National Science Foundation: Fiscal Years2011-2013 59Global Area of Biotech Crops by Country: 2011 60Biologics & Biotechnology R&D, PhRMA Member Companies: 2010 61Domestic & Foreign Pharmaceutical Sales, PhRMA Member Companies: 1975-2011 62Sales By Geographic Area, PhRMA Member Companies: 2010 63Domestic U.S. Biopharmaceutical R&D Breakdown, PhRMA Member Companies: 2010 64Domestic Biopharmaceutical R&D Scientific, Professional & Technical Personnel by Function,PhRMA Member Companies: 2010 65Domestic U.S. Biopharmaceutical R&D & R&D Abroad, PhRMA Member Companies: 1975-2011 66Chapter 3: Important Biotech & Genetics Industry Contacts 67(Addresses, Phone Numbers and Internet Sites)Chapter 4: THE BIOTECH 350:Who They Are and How They Were Chosen 106Industry List, With Codes 107Index of Companies Within Industry Groups 108Alphabetical Index 116Index of U.S. Headquarters Location by State 119Index of Non-U.S. Headquarters Location by Country 122Index by Regions of the U.S. Where the Firms Have Locations 124Index by Firms with International Operations 130Individual Profiles on Each of THE BIOTECH 350 132Additional IndexesIndex of Hot Spots for Advancement for Women/Minorities 487Index by Subsidiaries, Brand Names and Selected Affiliations 489

Companies Mentioned

23AndMe Inc3SBio Inc4SC AGAastrom Biosciences IncAbaxis IncAbbott LaboratoriesAccelrys IncAccess Pharmaceuticals IncActelion LtdAdamis Pharmaceuticals CorporationAdolor CorpAdvanced Cell Technology IncAdvanced Life Sciences Holdings IncAdvanSource Biomaterials CorporationAeolus Pharmaceuticals IncAEterna Zentaris IncAffymetrix IncAgenus IncAgilent Technologies IncAkorn IncAlbany Molecular Research IncAlcon IncAldagen IncAlexion Pharmaceuticals IncAlimera Sciences IncAlkermes plcAllergan IncAlliance Pharmaceutical CorpAllos Therapeutics IncAlseres Pharmaceuticals IncAmarin Corporation plcAmgen IncAmpliPhi Biosciences CorporationAmylin Pharmaceuticals IncAmyris Biotechnologies IncAnacor Pharmaceuticals IncAngiotech Pharmaceuticals IncAnika Therapeutics IncAPP Pharmaceuticals IncApplied Molecular Evolution IncApricus Biosciences IncAptalis PharmaAradigm CorporationArcadia Biosciences IncArena Pharmaceuticals IncAriad Pharmaceuticals IncArQule IncArray BioPharma IncArryx IncAstellas Pharma IncAstex Pharmaceuticals IncAstraZeneca CanadaAstraZeneca plcAvanir PharmaceuticalsAVAX Technologies IncAVIVA Biosciences CorpBASF SEBausch & Lomb IncBaxter International IncBayer AGBayer CorpBayer Healthcare PharmaceuticalsBIND Biosciences IncBio Rad Laboratories IncBioanalytical Systems IncBiocancell Therapeutics IncBiocompatibles International LtdBioCryst Pharmaceuticals IncBiogen IDEC IncBioheart IncBioMarin Pharmaceutical IncBiomet IncBioNano GenomicsBioReliance CorpBiosite IncBioTime IncBrachyTherapy Services IncBristol-Myers Squibb CoBroadSoft IncBurrill & CompanyCaliper Life Sciences IncCambrex CorpCangene bioPharma IncCangene CorpCaraco Pharmaceutical Laboratories LtdCardiome Pharma CorpCardium Therapeutics IncCegedim SACelera CorporationCelgene CorpCell Therapeutics IncCellartis ABCelldex Therapeutics IncCellular Dynamics InternationalCEL-SCI CorporationCelsis International plcCephalon IncCepheidCerus CorporationCharles River Laboratories International IncClaros Diagnostics IncCML Healthcare IncColumbia Laboratories IncComplete Genomics IncCompugen LtdCortex Pharmaceuticals IncCovance IncCovidien plcCrucell NVCSL LimitedCubist Pharmaceuticals IncCumberland Pharmaceuticals IncCuris IncCytRx CorporationDaiichi Sankyo Co LtdDainippon Sumitomo Pharma Co LtddeCODE genetics LtdDendreon CorporationDepomed IncdiaDexus IncDiscovery Laboratories IncDivi's Laboratories LimitedD-Medical Industries LtdDow AgroSciences LLCDr Reddy's Laboratories LimitedDSM Pharmaceutical Products IncDuPont (E I du Pont de Nemours & Co)DuPont Agriculture & NutritionDurect CorpDUSA Pharmaceuticals IncDyax CorpEisai Co LtdElan Corp plcEli Lilly & CompanyEmisphere Technologies IncEncorium Group IncEndo Health Solutions IncEntreMed IncEnzo Biochem IncEnzon Pharmaceuticals IncEpizymeeResearch Technology IncEUSA Pharma ( USA) IncEvotec AGExelixis IncFlamel Technologies SAForest Laboratories IncGalderma Pharma SAGE HealthcareGenencor International IncGenentech IncGenerex Biotechnology CorporationGenMark Diagnostics IncGenocea BiosciencesGenomic Health IncGen-Probe IncGenta IncGenVec IncGenzyme BiosurgeryGenzyme CorpGenzyme OncologyGeron CorporationGilead Sciences IncGlaxoSmithKline plcGTC Biotherapeutics IncHarbor BioSciences IncHarvard Bioscience IncHemagen Diagnostics IncHemispherx Biopharma IncHeska CorpHi-Tech Pharmacal Co IncHospira IncHuman Genome Sciences IncHycor Biomedical IncI3 CanReg IncICON plcIdera Pharmaceuticals IncIDEXX Laboratories IncIllumina IncImClone Systems IncImmtech Pharmaceuticals IncImmuCell CorporationImmunoGen IncImmunomedics IncImmunomedics IncIMPAX Laboratories IncIMS Health IncIncyte CorpIndependence Resources plcInfinity Pharmaceuticals IncInSite Vision IncInsmed IncInstitut Straumann AGIntegra Lifesciences Holdings CorpIntelliPharmaCeutics International IncInterMune IncInternational Isotopes IncIon TorrentIronwood Pharmaceuticals IncIsis Pharmaceuticals IncJazz Pharmaceuticals plcJohnson & JohnsonJoule Unlimited TechnologiesJubilant Biosys LtdKeryx Biopharmaceuticals IncKV Pharmaceutical CoLa Jolla Pharmaceutical CompanyLannett Company IncLexicon Pharmaceuticals IncLife Technologies CorpLifeCell CorporationLifecore Biomedical IncLigand Pharmaceuticals IncLonza Group LtdLorus Therapeutics IncLuminex CorporationMarina Biotech IncMaxygen IncMedicines Co (The)Medicis Pharmaceutical CorpMedidata Solutions IncMedimmune IncMEDTOX Scientific IncMerck & Co IncMerck KGaAMerck Serono SAMeridian Bioscience IncMetabolix IncMetabolon IncMillennium Pharmaceuticals IncMillipore CorpMonsanto CoMylan IncMyriad Genetics IncMyriad RBMNabi BiopharmaceuticalsNanoBio CorporationNavidea Biopharmaceuticals IncNektar TherapeuticsNeogen CorporationNordion IncNovartis AGNovavax IncNoven Pharmaceuticals IncNovo-Nordisk ASNovozymesNPS Pharmaceuticals IncNycomedObagi Medical Products IncOncoGenex Pharmaceuticals IncOncothyreon IncOnyx Pharmaceuticals IncOraSure Technologies IncOrchid Cellmark IncOre Holdings IncOrganogenesis IncOSI Pharmaceuticals LLCOtsuka Holdings Co LtdOXiGENE IncPacific Biosciences of California IncPain Therapeutics IncPalatin Technologies IncPar Pharmaceutical Companies IncPAREXEL International CorpPDL BioPharmaPeregrine Pharmaceuticals IncPerrigo CoPfizer IncPharmaceutical Product Development IncPharmacyclics IncPharmaNet/i3Pharmathene IncPharmos CorpPharsight CorpPioneer Hi-Bred International IncPolydex Pharmaceuticals LtdPoniard Pharmaceuticals IncPozen IncPRA InternationalProgenics Pharmaceuticals IncPromega CorpProtein Polymer Technologies IncQIAGEN NVQLT IncQuest Diagnostics IncQuestcor Pharmaceuticals IncQuintiles Transnational CorpRanbaxy Laboratories LimitedRaptor Pharmaceutical CorpRegeneron Pharmaceuticals IncRepligen CorporationRepros Therapeutics IncRigel Pharmaceuticals IncRoche Holding LtdS&W Seed CoSalix PharmaceuticalsSangamo BioSciences IncSanofi SASarepta Therapeutics IncSavient Pharmaceuticals IncSciClone Pharmaceuticals IncScios IncSeattle GeneticsSequenom IncSeraCare Life Sciences IncShionogi IncShire Canada IncShire plcSiemens Healthcare DiagnosticsSIGA Technologies IncSigma-Aldrich CorpSimcere Pharmaceutical GroupSkyePharma plcSoligenix IncSpecialty Laboratories IncSpectral Diagnostics IncSpectrum Pharmaceuticals IncSpherix IncStemCells IncStiefel Laboratories IncSynageva BioPharma CorpSynbiotics CorpSyngenta AGSynovis Life Technologies IncSynthetic Genomics IncTakeda Pharmaceutical Company LtdTamir Biotechnology IncTaro Pharmaceutical IndustriesTechne CorpTelik IncTengion IncTeva Parenteral Medicines IncTeva Pharmaceutical Industries LtdTG Therapeutics IncTheragenics CorpThermo Fisher Scientific IncThermo ScientificTitan Pharmaceuticals IncTOLMAR IncToyobo Co LtdTrinity Biotech plcTripos InternationalTrius Therapeutics IncUCB SAUnigene Laboratories IncUnited Therapeutics CorpUnited-Guardian IncUrigen Pharmaceuticals IncValeant Pharmaceuticals InternationalVentria BioscienceVerenium CorporationVermillion IncVernalis plcVertex Pharmaceuticals IncViaCord IncVical IncVirbac CorpViroPharma IncVivus IncWarner Chilcott plcWatson Pharmaceuticals IncWhatman plcXDX IncXenoPort IncXOMA CorporationZIOPHARM Oncology IncZogenix IncZymoGenetics Inc

To order this report:: Plunkett's Biotech & Genetics Industry Almanac 2013: Biotech & Genetics Industry Market Research, Statistics, Trends & Leading Companies

Contact Clare: clare@reportlinker.comUS:(339) 368 6001Intl:+1 339 368 6001


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