Reaxys® Medicinal Chemistry Provided As Part Of Elsevier's Suite Of Life Science Solutions Delivers High Quality Content To Improve Drug Discovery And Development

AMSTERDAM, February 4, 2013 /PRNewswire/ --

Comprehensive, referenced and well-structured data allows users to increase speed and accuracy of decision making in the drug development process

Elsevier, a world-leading provider of scientific, technical and medical information products and services, today announced the launch of Reaxys Medicinal Chemistry. It offers medicinal chemists access to comprehensive, referenced and well-structured data to enhance the compound selection process across discovery and pre-clinical stages in drug research and development. Reaxys Medicinal Chemistry will significantly improve the efficiency and productivity of researchers engaged in the process of designing compounds and optimizing their compatibility with one or more targets in order to successfully treat a disease.

Dr. Juergen Swienty-Busch, Product Lead for the Reaxys suite at Elsevier, said, "The greatest challenge of medicinal chemistry is to reduce the number of drug candidates that fail in late stages, significantly increasing the cost of bringing a drug to market. The well-known mantra 'fail early, fail cheap' is now central to the drug discovery process, with much of the responsibility borne by medicinal chemists."

Medicinal chemists develop strategies to find new drugs and to improve not only the efficacy of compounds but also selectivity, ADME properties and safety end-points. To support these strategies, medicinal chemists need to have access to up-to-date, well organized and high-quality experimental data on druggable targets, pharmacological effects, biological data points, and ADME properties associated with chemical compounds.

Reaxys Medicinal Chemistry sources its data from a vast repository of peer-reviewed journal articles, patents and regulatory information, encompassing millions of compounds and associated biological data linked to thousands of druggable proteins. It brings this information together into a single, easily searchable solution that gives pharmaceutical companies access to comparative data.

Reaxys Medicinal Chemistry can be used in conjunction with Elsevier's suite of life science products; including Reaxys, the leading chemistry discovery engine, and PharmaPendium, which focuses on regulatory approvals and drug safety. This solution effectively brings together lead identification, confirmation and drug repurposing.

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