Jan. 24, 2013
/PRNewswire/ -- Aethlon Medical, Inc. (OTCBB: AEMD), today released the following note authored by its Chairman and CEO,
Yesterday, our President
presented an informative review of extracorporeal medical device strategies to treat sepsis at the 15th International Conference on Dialysis. He also had the opportunity to discuss some of the advances we have made in the field. If you are not familiar with sepsis, it is a life-threatening blood infection that can trigger multiple organ failure and is a leading cause of death in intensive care units (ICU). 18 million cases of sepsis are diagnosed around the globe each year and candidate drug therapies have yet to demonstrate an ability to significantly improve survival rates.
When we initiated our sepsis research, the prevailing viewpoint seemed to be that sepsis was triggered by a hyperactive response of the immune system in an attempt to respond to overwhelming infection. This response is often called a "cytokine storm." As a result of this predominant viewpoint, many experimental therapies solely focused on modulating the early inflammatory response phase of sepsis and did so without much success. As it turns out, sepsis is far more complex as the exuberant inflammatory immune response occurring at the outset of sepsis is soon followed by a period of significant immune suppression. Thus, therapies solely focused on the knocking down the initial immune response may actually accelerate the development of immunosuppression, which is associated with a majority of deaths in sepsis. In other words, while sepsis is triggered by a hyper activation of the immune response, most sepsis patients actually die from immune paralysis.
As Rod points out in his presentation, evidence suggests that a successful extracorporeal strategy will have the ability to selectively eliminate multiple sepsis promoting factors from circulation without disrupting the production of anti-inflammatory cytokines or other elements that might further exasperate immune suppression. This is the focus of a strategy we are proudly advancing with industry colleagues under a contract with the Defense Advanced Research Projects Agency (DARPA).