This Day On The Street
Continue to site right-arrow
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
Stocks Under $10 with 50-100% upside potential - 14 days FREE!

Celgene's Abraxane: Two Month Survival Boost In Pancreatic Cancer Trial

Stocks in this article: CELG CELGZ THLD CLVS

In addition to the median 8-week survival advantage, Abraxane plus gemcitabine reduced the overall risk of death by 28% compared to gemcitabine alone.

At one year, 35% of Abraxane patients were still alive compared to 22% of patients in the control arm. Abraxane doubled the two-year survival rate but still only 9% of patients were alive at that point, a testament to the difficulty in treating pancreatic cancer.

Median progression-free survival favored Abraxane-gemcitabine over gemcitabine by 55 days (5.5 months vs. 3.7 months.) Twenty-three percent patients responded to Abraxane treatment compared to 7% in the control arm.

The most commonly reported serious toxicities associated with Abraxane were neutropenia (low white blood cell counts), fatigue and neuropathy, or nerve numbness/pain, reported in 17% of Abraxane-treated patients compared to 1% of gemcitabine-treated patients.

Gemcitabine is the current standard of care for pancreatic cancer even with the 2005 approval of Astellas and Roche's (RHHBY) Tarceva. FDA approved Tarceva in pancreatic cancer based on a study which demonstrated a short, 14-day median survival benefit over gemcitabine.

More recently, a four-drug chemotherapy regimen known as FOLFIRINOX demonstrated a 4.3-month survival benefit over gemcitabine (11.1 months versus 6.8 months) with 48% of pancreatic cancer patients treated with FOLFIRINOX alive at one year. However, the FOLFIRINOX regimen was also found to be very toxic, with 46% of patients reporting serious neutropenia, among other side effects.

Last year, Clovis Oncology (CLVS) reported disappointing results from a phase III study of its pancreatic cancer drug while Threshold Pharmaceuticals (THLD) moved its own product into phase III studies.

-- Reported by Adam Feuerstein in Boston.

Adam Feuerstein writes regularly for TheStreet. In keeping with company editorial policy, he doesn't own or short individual stocks, although he owns stock in TheStreet. He also doesn't invest in hedge funds or other private investment partnerships. Feuerstein appreciates your feedback; click here to send him an email.
2 of 2

Select the service that is right for you!

Action Alerts PLUS
Try it NOW

Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
  • Weekly roundups
TheStreet Quant Ratings
Try it NOW
Only $49.95/yr

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
  • Upgrade/downgrade alerts
Stocks Under $10
Try it NOW

David Peltier, uncovers low dollar stocks with extraordinary upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
  • Weekly roundups
Dividend Stock Advisor
Try it NOW

Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Alerts when market news affect the portfolio
  • Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
Real Money Pro
Try it NOW

All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.

Product Features:
  • Real Money + Doug Kass Plus 15 more Wall Street Pros
  • Intraday commentary & news
  • Ultra-actionable trading ideas
Options Profits
Try it NOW

Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • 100+ monthly options trading ideas
  • Actionable options commentary & news
  • Real-time trading community
  • Options TV
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!


DOW 17,804.80 +26.65 0.15%
S&P 500 2,070.65 +9.42 0.46%
NASDAQ 4,765.38 +16.9840 0.36%

Brokerage Partners

Rates from

  • Mortgage
  • Credit Cards
  • Auto

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs