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Genetic Basis Of High-risk Childhood Cancer Points To Possible New Drug Treatment Strategy

The authors are Ernesto Diaz-Flores and Mignon Loh, both of University of California School of Medicine, San Francisco; Michael Walsh, Jinghui Zhang, Debbie Payne-Turner, Michelle Churchman, Shann-Ching Chen, Kelly McCastlain, Jared Becksfort, Jing Ma, Gang Wu, Letha Phillips, Guangchun Song, John Easton, Matthew Parker, Xiang Chen, Michael Rusch, Kristy Boggs, Bhavin Vadodaria, Erin Hedlund, Christina Drenberg, Sharyn Baker, Deqing Pei, Cheng Cheng, Geoffrey Neale, David Ellison, Sheila Shurtleff, Ching-Hon Pui, Raul Ribeiro, Susana Raimondi and James Downing, all of St. Jude; Anna Andersson of St. Jude and Lund University Hospital, Sweden; Samir Patel and Susan Heatley, both formerly of St. Jude; Li Ding, Charles Lu, Robert Fulton, Lucinda Fulton, Yashodhan Tabib, David Dooling, Kerri Ochoa, Elaine Mardis and Richard Wilson, all of Washington University; Mark Minden, Princess Margaret Hospital/University Health Network, Toronto; Ian Lewis and L. Bik To, both of the Institute of Medical and Veterinary Science, Adelaide, Australia; Paula Marlton, Princess Alexandra Hospital, Queensland, Australia; Andrew Roberts, Royal Melbourne Hospital, Australia; Gordana Raca and Wendy Stock, both of University of Chicago School of Medicine; Hans Drexler, German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany; Ross Dickins, Walter & Eliza Hall Institute of Medical Research, Parkville, Australia; Meenakshi Devidas, University of Florida, Gainesville; Andrew Carroll, University of Alabama at Birmingham; Nyla Heerema and Julie Gastier-Foster, the Ohio State University; Brent Wood, Seattle Children's Hospital; and Michael Borowitz, Johns Hopkins Hospital, Baltimore.

The research was funded in part by the Pediatric Cancer Genome Project, including Kay Jewelers, a lead partner; The Henry Schueler 41&9 Foundation in conjunction with Partnership4Cures; the St. Baldrick's Foundation, grants (CA156329, CA21765, GM92666, CA98543, CA98413, CA114766 and CA023944) from the National Cancer Institute and National Institutes of Health; the AACR Gertrude B. Elion Cancer Research Award, Swedish Research Council and ALSAC.

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