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Diabetes, Metabolic Syndrome And Cardiovascular Disease

Table 3.13: Death Rate from Cardiovascular Diseases by Country, 2008 43

Table 3.14: Percentage of Adults Smokers by Country, 2008 47

Table 3.15: Selected Potential Patent Expirations of Cardiac Care Drugs, 2012-2013 48

Table 3.16: Worldwide Market for Cardiac Care Therapeutics, 2007-2014 49

Table 4.1: Global R&D Spending in the Pharmaceutical Industry, 2008-2012 56

Table 4.2: Pharmaceutical Companies Ranked by Total R&D Expenditures, 2011 56

Table 4.3: Leading Therapy Classes for R&D, 2012 57

Table 4.4: Global Pharmaceutical Sales by Region and Country, 2010 and 2015, and CAGR 2006-2010 and 2011-2015 58

Table 4.5: World Pharmaceutical Sales Share by Region, 2010 59

Table 4.6: Top Ten Global Pharmaceutical Companies by Global Sales, 2011 59

Table 4.7: Leading Ten Therapeutic Classes by U.S. Sales, 2006-2011 60

Table 4.8: Top Ten Therapeutic Classes by U.S. Dispensed Prescriptions, 2006-2011 60

Table 4.9: Leading Therapy Classes by Global Pharmaceutical Sales, 2015, and CAGR 2011-2015 61

Table 4.10: Top Selling Drugs in the U.S., 2010 61

Table 4.11: Worldwide Anti-Diabetes Drug Market, 2008-2016 63

Table 4.12: Oral Anti-Diabetic Therapy Major World Markets, 2010 63

Table 4.13: The Leading Five Anti-Diabetics by Sales, 2011 65

Table 4.14: American College of Physicians 2012 Practical Guideline for the Use of Anti-Diabetes Drugs for Type 2 Diabetes 66

Table 4.15: Summary of Glucose-Lowering Interventions as Monotherapy 70

Table 5.1: Classes of Non-Insulin Hypoglycemic Agents 73

Table 5.2: Non-Insulin Hypoglycemic Drugs Used to Treat Type 2 Diabetes, 2012 75

Table 5.3: Relative Efficacy of Diabetes Drugs 75

Table 5.4: Average Dose and Cost Comparison of Oral Hypoglycemic Agents 76

Table 5.5: Fixed-Dose Oral Anti-Diabetes Drug Combinations 88

Table 5.6: Delivery Method of Non-Insulin Anti-Diabetes Drugs in the Pipeline, 2011 93

Table 5.7: GLP-1 Agonist Pipeline: Selected Drugs in Development that Target GLP-1 94

Table 5.8: DPP-IV Inhibitor Pipeline 95

Table 5.9: Summary of Emerging Non-Insulin Anti-Diabetes Drug Categories 97

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