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Diabetes, Metabolic Syndrome And Cardiovascular Disease

Figure 5.3: Global Non-Insulin Anti-Diabetes Sales by Drug Class, 2010 89

Figure 5.4: Global Non-Insulin Anti-Diabetes Prescriptions by Drug Class, 2010 90

Figure 5.5: Sales Forecast for the Global Diabetes Drug Market, 2008-2016 91

Figure 5.6: Sales Forecast for the U.S. Diabetes Drug Market, 2008-2016 92

Figure 6.1: Global Sales of Lantus, 2005-2011 104

Figure 6.2: Insulin Pump Market Share, 2011 141

INDEX OF TABLES

Table 2.1: Top Ten Countries with the Largest Estimated Number of Diabetics (20 to 79 Years Age Group), 2012 and 2030 17

Table 2.2: U.S. Population of Diabetics (Diagnosed and Undiagnosed) Aged 20 Years or Older, 2010 19

Table 2.3: Cost of Diagnosed Diabetes in the U.S., 2007 21

Table 2.4: Medical Care Costs Attributable to Diabetes in the U.S., 2010 22

Table 2.5: Healthcare Utilization by Diabetic Patients 22

Table 2.6: Annual Cost of Care of UnitedHealthcare Adult Members with Diabetes, 2009 23

Table 2.7: Per-Event Costs of Diabetes Complications 24

Table 3.1: International Diabetes Federation (IDF) Diagnostic Criteria for Metabolic Syndrome 28

Table 3.2: American Heart Association and National Heart, Lung, and Blood Institute (AHA/NHLBI) Diagnostic Criteria for Metabolic Syndrome 28

Table 3.3: Additional Metabolic Criteria for Research 30

Table 3.4: Ten Leading Diagnoses for Co-Morbid Chronic Diseases in the U.S. 37

Table 3.5: Odds Ratio of Progression to Complications Associated with Type 2 Diabetes 39

Table 3.6: Prevalence of Complications Among Patients with Diabetes 39

Table 3.7: Novel Risk Factors and Possible Mechanisms of the Excess Risk of Coronary Heart Disease in Type 2 Diabetes Mellitus 39

Table 3.8: Major Causes of End-Stage Renal Disease 39

Table 3.9: Clinical Recommendations for Adults with Diabetes 40

Table 3.10: Laboratory Assessment of Diabetic Vascular Disease 40

Table 3.11: Average Years Gained Free of Diabetes-related Disease with Intensive Management 41

Table 3.12: Summary of Cardiovascular Diseases (CVDs) 41

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