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Diabetes, Metabolic Syndrome And Cardiovascular Disease

5.1.10 Comparisons of the Anti-Diabetes Drugs 88

5.2 Drivers and Trends 89

5.2.1 Market Share of Anti-Diabetic Drugs 89

5.2.2 Forecasts for Anti-Diabetic Drugs 90

5.2.3 Sales Forecast for the Global Diabetes Market 91

5.3 The Future 92

5.3.1 Practice Patterns 92

5.3.2 New Products in Pipeline 92

5.3.2.1 Novel GLP-1 Agonists and Analogs 93

5.3.2.2 Novel DPP-IV Inhibitors 94

5.3.2.3 Sodium Glucose Cotransporter 2 (SGLT-2) 95

5.3.2.4 Emerging Non-Insulin Anti-Diabetes Targets and Drugs in the Pipeline 96

5.3.2.5 Novel Approaches to Finding New Drug Targets 99

5.4 Anti-Diabetic Drug Patent Expiry 100

5.5 Regulatory Issues 100

6. Insulin 1016.1 Insulin Markets 1016.1.1 Major Players and Market Share 1026.1.2 Patent Expirations 1046.1.3 Innovation Strategies 1046.2 Insulin Therapeutics 1056.2.1 Recommendations for Insulin Initiation and Administration 1056.2.2 Short-Acting Insulin 1086.2.3 Rapid-Acting Insulin 1086.2.4 Intermediate-Acting Insulin 1106.2.5 Long-Acting Insulin 1106.2.6 Long-Acting Insulins in Development 1116.2.7 Insulin Mixtures 1126.3 Pipeline Insulin 1126.4 Non-Invasive Insulin Delivery 1136.4.1 Inhaled Insulin 1146.4.1.1 A Chronicle of Inhaled Insulins 1156.4.2 Oral Insulin 1176.4.3 Transdermal Insulin 1206.5 Barriers for Non-Injected Insulin 1226.6 Patient Potential for Non-Injected Insulin 1226.7 Insulin Delivery Devices 1226.7.1 Insulin Pens 1236.7.2 Injections Aids 1286.7.2.1 Automatic Injectors 1296.7.2.2 Syringe Magnifiers 1296.7.2.3 Injection Ports 1306.7.3 Insulin Jet Injectors 1306.7.4 Insulin Pumps 1316.7.4.1 External Insulin Pumps 1326.7.4.2 Insulin Infusion Sets 1366.7.4.3 Insulin Patch Pumps in Development or Only Available Outside the U.S. 1376.7.4.4 Implantable Insulin Pumps 1396.7.4.5 Insulin Pump Market Share 1416.7.4.6 Drivers of Demand for Pumps 1426.8 Market Forecasts for Insulin Administration Technologies 142

7. Emerging Anti-Diabetes Technologies and Products 143

7.1 Projections for the Anti-Diabetes Drug Market 143

7.2 Artificial Pancreas 146

7.3 Insulin-Producing Cells 147

7.3.1 Cell Therapy Companies for Diabetes 148

7.4 Pancreatic Transplantation 149

7.4.1 Candidates for Pancreatic Transplantation 150

7.4.1.1 Pancreatic Organ Transplantation 151

7.4.1.2 Allo-Islet Transplantation 151

7.4.1.3 Implantation of Genetically Engineered b-Cells or Embryonic Stem Cells 151

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