The BED was established at 60 mg/m2 daily for 5 days and the drug was well tolerated by both MDS and AML patients up to 90 mg/m2 daily for 5 days. Two patients had dose limiting toxicities (DLT's), mainly febrile neutropenia, thrombocytopenia and sepsis, out of 12 patients treated at the highest dose of 125 mg/m2 daily for 5 days.The dose expansion part of the study is ongoing, and patients with AML (first-line elderly; or relapsed/refractory) and first line MDS are being randomized to either 60 or 90 mg/m2 daily for 5 days. A third arm was added to investigate the dose of 60 mg/m2 daily for 10 days in relapsed/refractory AML.
Astex Pharmaceuticals Announces Results From Dose Escalation Part Of SGI-110 Phase 1/2 MDS And AML Study In An Oral Presentation At ASH
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