The Phase 2 trial, evaluating ibrutinib in combination with rituximab, was led by Jan A. Burger, M.D., Ph.D., associate professor, Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX."We are very excited by the response rates we saw with ibrutinib-rituximab combination therapy, and believe they emphasize the need for rapid, further development of ibrutinib, especially for patients with high-risk CLL/SLL," said Dr. Burger.
- The overall response rates were:
- 68 percent in TN patients, all of whom were over 65 years old, after a median follow up of 20.3 months
- 71 percent in patients with RR disease, including patients with HR CLL/SLL, after a median follow up of 15.7 months
- The estimated PFS at 26 months is 96 percent for patients over 65 years of age with TN CLL and 75 percent for those with RR/HR disease
- Estimated OS at 26 months is 96 percent in TN patients and 83 percent in patients with RR/HR disease