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Global Anticoagulants Industry

The ARISTOTLE Trial II-19

Eliquis - More Promising than Existing Oral Anticoagulants II-20

Competitors Capitalize on Delay in Eliquis' Approval II-20

Do New Oral Anticoagulants Circumvent Issues with

Conventional Drugs? II-20

Hemostatic Agents for Reversing Action of New Oral Drugs - An

Area Demanding Active Research II-21

 

4. INJECTABLE ANTICOAGULANTS II-22

Injectable Anticoagulants- An Insight II-22

Heparin - The Back Bone of Injectable Anticoagulants II-22

Unfractionated Heparin II-22

Advantages and Alternatives II-23

Limitations II-23

Low Molecular Weight Heparins II-23

Indications II-24

Advantages II-24

Contraindications II-25

Side Effects II-25

Caution II-25

Costs II-25

Impediments II-25

A Focus on Select Heparin Based Injectables II-26

Lovenox/Clexane (enoxaparin) II-26

Approved Indications for Lovenox II-26

Advantages and Alternatives II-26

Table 2: World Lovenox Sales by Geographic Region

(2009-2011): Breakdown of Value Sales in US$ Million for

Western Europe, US, Emerging Markets and Others (includes

corresponding Graph/Chart) II-27

Fragmin (dalteparin sodium) II-27

Approved Indications for Fragmin Use II-28

Contraindications II-28

Precautions II-29

Fraxiparine (nadroparin) II-29

Innohep (tinzaparin) II-29

Contraindications II-30

Side Effects II-30

Other Serious Adverse Events Associated with Innohep II-31

Precautions II-31

Normiflo (ardeparin) II-31

Clivarine (reviparin) II-32

Table 3: Summary of Available LMWHs II-32

A Comparison of FDA Approved Indications for Select Injectable

LMWHs - Lovenox, Innohep and Fragmin II-33

Non-Heparin Anticoagulant Injectables - An Overview II-33

Arixtra (fondaparinux) II-33

Contraindications II-34

Market and Market Participants II-34

Angiomax (bivalirudin) II-34

Advantages II-35

Contraindications II-35

Side Effects II-35

Argatroban/Novastan II-35

Side Effects II-36

Precautions II-36

Refludan (lepirudin) II-36

Orgaran (danaparoid Sodium) II-37

Contraindications II-37

Side Effects II-38

Caution II-38

Precaution II-38

A Comparative Analysis of Various Direct Thrombin Inhibitors II-38

 

5. A COMPARATIVE STUDY OF ANTICOAGULANT THERAPIES II-39

A Comparative Study of Warfarin Against LMWHs II-39

A Comparative Study of LMWH Against UFH II-40

A Comparative Study of New Anticoagulants/ Anticoagulant

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