This Day On The Street
Continue to site right-arrow
ADVERTISEMENT
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
TheStreet Open House

Celldex Therapeutics Announces Upcoming Data Presentations On CDX-1127 And CDX-011

Celldex Therapeutics, Inc. (NASDAQ: CLDX) today announced upcoming data presentations on two of the Company’s fully human monoclonal antibody programs—CDX-1127 and CDX-011.

Tibor Keler, PhD, Senior Vice President and Chief Scientific Officer, will present a review of the CDX-1127 program at the IBC’s Antibody Engineering & Antibody Therapeutics Meeting on Thursday, December 6, 2012 at 3:15 pm PT (6:15 pm ET) at the Hilton San Diego Bayfront Hotel in San Diego, California. The presentation will include a comprehensive review of preclinical results. CDX-1127 binds CD27, an important co-stimulatory molecule on T cells, and is designed to activate patients' immune cells against their cancer. The Company is currently conducting a two-arm, multi-dose, Phase 1 study in patients with selected malignant solid tumors or hematologic malignancies to determine a Phase 2 dose for further development. The solid tumor arm is completing accrual in the final dose cohort and, to date, has been well tolerated, including at the highest dose level. The Company continues to enroll patients in the hematologic arm and expects to complete enrollment in this arm in the first half of 2013. Clinical results from both studies will be presented at a future medical meeting.

Denise A. Yardley, MD, Senior Investigator in the Breast Cancer Research Program at the Sarah Cannon Research Institute and a lead investigator in the Phase 2b EMERGE study of CDX-011 in metastatic breast cancer, will present mature results in a poster session at the San Antonio Breast Cancer Symposium on Saturday, December 8, 2012 at 7:00 am CT (8:00 am ET) at the Henry B. Gonzalez Convention Center in San Antonio, Texas. The Company anticipates the presentation will include overall survival and duration of response data and updated patient response and progression free survival data. The Company will issue a press release at the time of the presentation and will make a copy of the poster available on their website in the “Product Pipeline, Scientific Presentations” section. CDX-011 targets and binds to GPNMB, a specific protein expressed in breast cancer that promotes the migration, invasion and metastasis of the disease. In May of 2012, the Company reported preliminary positive results from the Phase 2b study, noting particularly impressive response rates in patients with triple negative breast cancer who also have high (≥ 25%) levels of GPNMB expression.

1 of 3

Check Out Our Best Services for Investors

Action Alerts PLUS

Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
Quant Ratings

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
Stocks Under $10

David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
14-Days Free
Try it NOW
Only $9.95
Try it NOW
14-Days Free
Try it NOW

Check Out Our Best Services for Investors

Dividend Stock Advisor

David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks

Every recommendation goes through 3 layers of intense scrutiny—quantitative, fundamental and technical analysis—to maximize profit potential and minimize risk.

Product Features:
  • Model Portfolio
  • Intra Day Trade alerts
  • Access to Quant Ratings
Options Profits

Our options trading pros provide over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • Actionable options commentary and news
  • Real-time trading community
Try it NOW
Try it NOW
Try it NOW
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!
SYM TRADE IT LAST %CHG

Markets

DOW 17,712.66 +34.43 0.19%
S&P 500 2,061.02 +4.87 0.24%
NASDAQ 4,891.2190 +27.8570 0.57%

Partners Compare Online Brokers

Free Reports

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs