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TheStreet Open House

Global Hemoglobin A1c Monitoring Industry

Purposes? II-4

Near Patient Testing Gaining Ground II-5

POC Testing Versus Lab-Based Testing II-5

Glycated Albumin - A Potential Threat to HbA1c? II-5

HbA1c Level Customization for Patients - A Part of the New

Guidelines II-6

Complex Competitive Environment Prevails in POC Diagnostics

Market II-6

Major Benefits of POC HbA1c Tests II-6

Enhanced Patient Care II-6

Quality Results at par with Laboratory Tests II-7

Compact Size II-7

Ease-of-Use II-7

Convenience to Patients II-7

Major Testing Methods in POC HbA1c Tests II-7

Immunoassays II-8

Boronate Affinity Chromatography II-8

Micro-Optical Detection Methods II-8

Leading HbA1c Tests in the Market - A Comparison II-9

Non-Invasive Glucose Meters Threatens HbA1c Market II-10

2. PRODUCT OVERVIEW II-11

Product Definition II-11

Hemoglobin - A Brief II-11

Hemoglobin A1c- Description II-11

HbA1c Monitoring II-11

What is A1c II-11

1. HbA1c Laboratory Testing II-12

2. HbA1c Point of Care Testing & Self-Monitoring II-12

Hemoglobin A1c (HbA1c) Test II-12

Interpreting HbA1c Test Readings II-13

Interpreting HbA1c Test Readings II-13

Result of Hemoglobin A1c Test II-13

Clinical Use of A1c Testing II-13

Advantages of A1c Assessment & Interpretation II-14

Risks Associated with HbA1c Testing II-14

Methods of Measurement for Glycohemoglobin II-14

Why Opt for HbA1c Testing? II-15

The Diabetes Control & Complications Trial (DCCT) II-15

The Kumamoto and UK Prospective Studies II-15

Glycemia Tests Used In Monitoring Diabetes II-15

Urine Glucose Testing II-15

Glycated Protein Testing II-16

Table 1: Relation Between A1c Level and Mean Plasma

Glucose Levels II-16

HbA1c Test Types II-17

HbA1c Laboratory Testing II-17

HbA1c Laboratory Testing Product Development Over the Years II-17

HbA1c Point of Care Testing & Self-Monitoring II-20

3. DIABETES - A BRIEF PROFILE OF THE DISEASE II-22

What Causes Diabetes II-22

Types of Diabetes II-22

Major Types of Diabetes II-23

Likely Complications II-23

Nephropathy (Kidney Disease) II-23

Diabetic Neuropathy (Nerve Damage) II-23

Retinopathy (Damage to the Eye and Blindness) II-24

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