This Day On The Street
Continue to site right-arrow
ADVERTISEMENT
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
$1 buys you full access to ALL of TheStreet's Subscription Services! Learn More

Compugen Presents At American Association Of Cancer Research Special Conference On Tumor Immunology

Stocks in this article: CGEN

Speaking today at the American Association of Cancer Research Special Conference on Tumor Immunology in Miami, Florida, Dr. Ofer Levy, Senior Scientist at Compugen Ltd., presented data supporting the therapeutic potential of CGEN-15001T and CGEN-15022, proteins discovered by Compugen, as immune checkpoint targets for cancer immunotherapy. This prestigious conference features talks by key opinion leaders, invited to discuss new findings in the field of tumor immunology. Presentations cover both basic and translational research, highlighting rapidly developing advances in this breakthrough approach to cancer treatment.

CGEN-15001T and CGEN-15022 are both membrane proteins which were predicted and validated by Compugen as novel B7/CD28-like immune checkpoint candidates. Such checkpoint proteins are expressed on the surface of cancer cells and other cells within the tumor microenvironment, and their negative immune activities protect the tumor from being attacked by the immune system. Both Compugen targets have shown robust inhibitory activity in different assays of T cell activation, and in his talk, Dr. Levy presented some of these findings. The robust inhibitory activities of these novel immune checkpoints, which were previously demonstrated using each target's extracellular domain fused to an Fc antibody fragment, have now also been shown for the targets’ native membrane forms, which is an important finding for antibody targets.

In his talk, Dr. Levy presented expression profile data for CGEN-15001T and CGEN-15022 in various cancer types, demonstrating substantially different expression patterns for the two drug targets. As previously disclosed, CGEN-15001T is expressed in various solid cancers and hematological malignancies, including prostate cancer, melanoma, Hodgkin's lymphoma and Non-Hodgkin's lymphoma, such as T and B cell lymphomas. In addition, CGEN-15001T was shown to be expressed in the infiltrating immune cells within the tumor, further supporting an immunomodulatory role for this target in cancer development. In comparison, CGEN-15022 is highly expressed in liver, lung, breast, colorectal, prostate and ovarian cancers, as described today by Dr. Levy. The high expression levels observed in these cancers compared with their respective normal cells support the development of antibodies with high specificity toward the cancer cells.

1 of 2

Select the service that is right for you!

COMPARE ALL SERVICES
Action Alerts PLUS
Try it NOW

Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
  • Weekly roundups
TheStreet Quant Ratings
Try it NOW
Only $49.95/yr

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
  • Upgrade/downgrade alerts
Stocks Under $10
Try it NOW

David Peltier, uncovers low dollar stocks with extraordinary upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
  • Weekly roundups
Dividend Stock Advisor
Try it NOW

Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Alerts when market news affect the portfolio
  • Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
Real Money Pro
Try it NOW

All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.

Product Features:
  • Real Money + Doug Kass Plus 15 more Wall Street Pros
  • Intraday commentary & news
  • Ultra-actionable trading ideas
Options Profits
Try it NOW

Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • 100+ monthly options trading ideas
  • Actionable options commentary & news
  • Real-time trading community
  • Options TV
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!
DOW 17,810.06 +91.06 0.51%
S&P 500 2,063.50 +10.75 0.52%
NASDAQ 4,712.97 +11.1030 0.24%

Brokerage Partners

Rates from Bankrate.com

  • Mortgage
  • Credit Cards
  • Auto

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs