This Day On The Street
Continue to site
ADVERTISEMENT
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here

The ALS Association Announces New Research Awards To Focus On Therapies For Lou Gehrig's Disease

WASHINGTON, Nov. 30, 2012 /PRNewswire-USNewswire/ -- The ALS Association will add ten awards totaling $2.9 million to its Translational Research Advancing Therapies for ALS (TREAT ALS™) portfolio, funding two clinical management grants, three drug discovery contracts, two clinical pilot studies and three biomarker studies—all focused on finding improved treatments for people with amyotrophic lateral sclerosis (ALS), otherwise known as Lou Gehrig's disease. The ALS Association's TREAT ALS ™ portfolio presently has 80 active research projects with a total award value of $12 million.

Due to the deadly and often rapid nature of ALS, a need exists for treatments and a cure for this disease as there is only one drug approved by the U.S. Food and Drug Administration (FDA) that modestly extends survival. ALS is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Eventually, people with ALS lose the ability to initiate and control muscle movement, which often leads to total paralysis and death within two to five years of diagnosis. For unknown reasons, veterans are twice as likely to develop ALS as the general population.

The two clinical management grants, which intend to expand access to care for people with ALS will analyze remote forms of treatments. Edward Kasarskis, M.D., and Richard Kryscio, Ph.D., with the University of Kentucky Research Foundation in Lexington, Ky. will devise and monitor a virtual ALS center that could provide people with the disease with multidisciplinary care remotely in their homes. James Berry, M.D., and Merit Cudkowicz, M.D., with the Massachusetts General Hospital in Boston, Mass. have devised a "telehealth" initiative to assess a videoconferencing program that offers home health providers tools to provide care to people with ALS in homes.

The three drug discovery contracts awarded by The ALS Association will support the pre-clinical assessment of therapeutics for the disease, and researchers expect they will lead to the progress of new therapies for ALS. Researchers leading these projects include: Oleg Butovsky, Ph.D., with Brigham and Women's Hospital in Boston, Mass.; Steven Burden, Ph.D., with Skirball Institute, New York University Medical School, in New York; and Rita Sattler, Ph.D., and Jeffrey Rothstein, M.D., Ph.D., at Johns Hopkins University School of Medicine in Baltimore, Maryland.

In addition to the clinical management grants and drug discovery contracts, The ALS Association is supporting two novel clinical pilot studies involving people with ALS with the Northeast ALS Consortium (NEALS) Clinical Trials Network. Jonathan Glass, M.D., and Christina Fournier, M.D., with Emory University in Atlanta, along with Merit Cudkowicz, M.D., and James Berry M.D., in Boston, Mass. will work together to determine whether they can identify a subset of people with ALS that respond to immune suppressing medication. Additionally, Jeremy Shefner, M.D., Ph.D., with SUNY Upstate Medical University in Syracuse, N.Y. will test Cogane™, a small, non-peptide agent that can penetrate the brain and spinal cord, which has been shown to improve the number of functional motor units and increased the life span in mouse models of ALS.

The ALS Association will also fund three biomarker studies, which could accelerate diagnosis of the disease and hasten clinical trials. Two of the three studies were supported by EMD/ALS Biomarker Research Fund through the Keith Worthington Chapter of The ALS Association.  Researchers include Michael Benatar, M.D., and Joanne Wuu, both with the University of Miami Miller School of Medicine in Miami, Fla., who will look for predictive biomarkers in patients with a genetic form of the disease before they develop symptoms. Patricia Anders, MHG, Boston, Mass. will develop a strength testing device that may more accurately measure response to therapy.  And finally, Lyl Ostrowe, M.D., Ph.D.; Dean Wong, M.D., Ph.D. and Jeffrey Rothstein, M.D., Ph.D., all with Johns Hopkins University, will assess whether a PET imaging marker can accurately distinguish between people with ALS and healthy subjects.

To view a full listing of these awards, please visit www.alsa.org/researchawards2012.

About The ALS Association

The ALS Association is the only national non-profit organization fighting Lou Gehrig's Disease on every front.  By leading the way in global research, providing assistance for people with ALS through a nationwide network of chapters, coordinating multidisciplinary care through certified clinical care centers, and fostering government partnerships, The Association builds hope and enhances quality of life while aggressively searching for new treatments and a cure.  For more information about The ALS Association, visit our website at www.alsa.org.

SOURCE The ALS Association

Copyright 2011 PR Newswire. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Check Out Our Best Services for Investors

Action Alerts PLUS

Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
Quant Ratings

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
Stocks Under $10

David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
14-Days Free
Only $9.95
14-Days Free
Dividend Stock Advisor

David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks

Every recommendation goes through 3 layers of intense scrutiny—quantitative, fundamental and technical analysis—to maximize profit potential and minimize risk.

Product Features:
  • Model Portfolio
  • Intra Day Trade alerts
  • Access to Quant Ratings
Options Profits

Our options trading pros provide over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • Actionable options commentary and news
  • Real-time trading community
SYM TRADE IT LAST %CHG

Markets

Chart of I:DJI
DOW 17,600.53 +49.84 0.28%
S&P 500 2,093.32 -4.72 -0.22%
NASDAQ 5,105.5460 -9.8360 -0.19%

Free Reports

Top Rated Stocks Top Rated Funds Top Rated ETFs