Threshold shares rose more than six-fold in value between Feb. 1 and March 30, reaching a high of $8.80 per share. Unfortunately, investor enthusiasm for TH-302 has waned, clipped by concerns about the drug's ability to prolong survival in a phase III study expected to start next year. The recently announced positive results from a phase III study of Celgene's (CELG) Abraxane in pancreatic cancer also added competitive pressure to Threshold. At $4.46, the Threshold market value has been cut in half since those heady days of February and March.
6. Hemispherx Biopharma (HEB) +292%
Hemispherx's performance this year looks impressive on a blind percentage basis, but less so when you consider the stock began the year's trading at 20 cents per share. Shares closed at $1 just once.
The only attention Hemispherx is getting comes from day traders and biotech "run-up" traders anticipating the Dec. 20 FDA advisory panel for the company's chronic fatigue syndrome therapy Ampligen.
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