Cabozantinib is an oral drug designed to block two major molecular pathways by which tumor cells grow. In the phase III study of advanced MTC patients, treatment with cabozantinib resulted in a median progression-free survival of 11.2 months compared to 4 months for patients treated with a placebo. Cabozantinib reduced the risk of MTC re-growth by 72% compared to placebo.
In phase II studies of men with advanced prostate cancer, cabozantinib has shown the potential to reduce or halt the spread of tumors to bones as well as reduce pain.
-- Reported by Adam Feuerstein in Boston.