About PREMIERPREMIER was a Phase 3, randomized, controlled trial in MTX-naïve patients with early moderate to severe RA. Patients received MTX, HUMIRA 40 mg eow or HUMIRA 40 mg eow plus MTX for two years of blinded treatment. The co-primary endpoints were ACR 50 response and mean change from baseline in mTSS at week 52 for the HUMIRA + MTX combination therapy arm versus the MTX monotherapy. Results of this trial demonstrated the radiographic, clinical and functional superiority of initial combination therapy over the individual monotherapies.
About HUMIRA ® (adalimumab)
UsesHUMIRA (adalimumab) is a prescription medicine used alone, with methotrexate, or with certain other medicines to reduce the signs and symptoms of moderate to severe rheumatoid arthritis in adults. It may prevent future damage to bones and joints and may help with the ability to perform daily activities.
Important Safety InformationHUMIRA is a TNF blocker medicine that affects the immune system and can lower the ability to fight infections. Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. People should be tested for TB before HUMIRA use and monitored for signs and symptoms of TB during therapy. People at risk of TB may be treated with medicine for TB. Treatment with HUMIRA should not be started in a person with an active infection, unless approved by a doctor. HUMIRA should be stopped if a person develops a serious infection. People should tell their doctor if they live in or have been to a region where certain fungal infections are common, have had TB, hepatitis B, are prone to infections, or have symptoms such as fever, fatigue, cough, or sores.For people taking TNF blockers, including HUMIRA, the chance of getting lymphoma or other cancers may increase. Some people have developed a rare type of cancer called hepatosplenic T-cell lymphoma. This type of cancer often results in death. If using TNF blockers including HUMIRA, the chance of getting two types of skin cancer (basal cell and squamous cell) may increase. These types are generally not lifethreatening if treated.
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