This Day On The Street
Continue to site
ADVERTISEMENT
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here

BioCryst Broad-Spectrum Antiviral BCX4430 Highly Effective Against Yellow Fever In A Preclinical Disease Model

BioCryst Pharmaceuticals, Inc. (NASDAQ:BCRX) today announced proof-of-principle data demonstrating that BCX4430 is efficacious and well tolerated in a preclinical disease model for evaluating efficacy against yellow fever virus infection. BCX4430 is the lead compound in BioCryst’s broad-spectrum antiviral (BSAV) research program. The objective of BioCryst’s BSAV program is to develop broad-spectrum parenteral and oral therapeutics for viruses that pose a threat to national health and security.

A presentation entitled “BCX4430, an adenosine analog, with potent activity against yellow fever virus in a hamster model,” will be presented by Dr. Justin Julander at the 2nd Antivirals Congress in Cambridge, MA today at 5:10PM E.T.

These studies comprehensively evaluated the efficacious dose, dose duration, and therapeutic use of parenteral BCX4430 in the treatment of yellow fever infection. Syrian Golden Hamsters–a widely accepted model for establishing efficacy against yellow fever —virus were inoculated intraperitoneally with ten times the cell culture infectious dose (CCID 50) of yellow fever virus (Jimenez strain) and treated parenterally with BCX4430 administered either once or twice daily for 4 to 7 days. In studies with treatment just prior to infection or delayed up to 4 days after infection, BCX4430 treated animals had significantly (p<0.001) improved survival (80–100%) compared to animals receiving saline placebo (20-30%). It is important to note that in this model, serum viral titers peak at day four after infection, indicating that BCX4430 has the potential to be an effective therapeutic when administered as pre-exposure prophylaxis; as post-exposure prophylaxis during the virus incubation period; and as a treatment during the prodromal period and symptomatic disease. Treated animals also exhibited significantly lower viral titers in serum, improved weight gain, and decreased liver damage as measured by lower levels of alanine transaminase and aspartate transaminase.

In addition, BCX4430 demonstrated a wide therapeutic index of 50 with a minimum effective dose of 4 mg/kg/day (p<0.05 vs control), as measured by survival, and a maximum tolerated dose of 200 mg/kg/day, as measured by percent weight change.

1 of 3

Check Out Our Best Services for Investors

Action Alerts PLUS

Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
Quant Ratings

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
Stocks Under $10

David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
14-Days Free
Only $9.95
14-Days Free
Dividend Stock Advisor

David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks

Every recommendation goes through 3 layers of intense scrutiny—quantitative, fundamental and technical analysis—to maximize profit potential and minimize risk.

Product Features:
  • Model Portfolio
  • Intra Day Trade alerts
  • Access to Quant Ratings
Options Profits

Our options trading pros provide over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • Actionable options commentary and news
  • Real-time trading community
SYM TRADE IT LAST %CHG

Markets

Chart of I:DJI
DOW 16,374.76 +23.38 0.14%
S&P 500 1,951.13 +2.27 0.12%
NASDAQ 4,733.4970 -16.4820 -0.35%

Free Reports

Top Rated Stocks Top Rated Funds Top Rated ETFs