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3-V Biosciences Presents Positive Preclinical Data On HCV Product Candidates Targeting FASN At The American Association For The Study Of Liver Disease Annual Meeting 2012

MENLO PARK, Calif., Nov. 10, 2012 /PRNewswire/ -- 3-V Biosciences, Inc., announced today that preclinical data for its novel fatty acid synthase (FASN) inhibitors for the treatment of chronic hepatitis C virus (HCV) infection will be presented at the 63 rd Annual Meeting of the American Association for the Study of Liver Diseases (The Liver Meeting ®) being held November 9-13 in Boston, Massachusetts. 

(Logo:   http://photos.prnewswire.com/prnh/20121001/LA83573LOGO)

"New, potent therapeutics that combine with and improve on the evolving standard of care for the treatment of hepatitis C infection are needed to ensure that we can reach the broadest population of patients with appropriate, curative regimens," said George Kemble, Chief Scientific Officer of 3-V Biosciences.  "3-V's FASN inhibitors represent an entirely new class of therapy.  With a novel mechanism of action, and broad-spectrum, potent antiviral activity demonstrated across multiple preclinical studies, we believe that our FASN inhibitors will bring substantial benefits to patients as a key component in emerging multi-drug treatment regimens.  We look forward to initiating clinical studies early next year."

Novel FASN Inhibitors3-V's FASN inhibitors for the treatment of HCV are designed to have broad-spectrum activity, a high barrier to resistance and the ability to combine with direct-acting antivirals, such as nucleotide/nucleoside inhibitors, protease inhibitors, NS5a inhibitors and other mechanisms of action currently in development.  Data characterizing the preclinical antiviral activity of 3-V's FASN inhibitors will be featured in oral and poster presentations during The Liver Meeting.  Highlights of these data include:

  • Orally bioavailable representative molecules are potent and specific, with IC50s in the 5-50nM range;
  • Inhibitors have demonstrated excellent exposure and low toxicity in rodents associated with prolonged in vivo suppression of FASN;
  • Antiviral activity against wild-type Genotype 1a, 1b and 2a replicons; and
  • Antiviral activity against mutant HCV replicons resistant to NS3, NS4b, NS5a and NS5b inhibitors.

3-V's FASN inhibitors are a chemically diverse set of potent, specific, reversible molecules with an excellent range of pharmaceutical properties.  The company has filed multiple worldwide patent applications covering these inhibitors.  3-V's HCV program is on track for an IND in the first quarter of 2013 and the company anticipates clinical proof-of-concept data by year-end 2013.

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