- Orally bioavailable representative molecules are potent and specific, with IC50s in the 5-50nM range;
- Inhibitors have demonstrated excellent exposure and low toxicity in rodents associated with prolonged in vivo suppression of FASN;
- Antiviral activity against wild-type Genotype 1a, 1b and 2a replicons; and
- Antiviral activity against mutant HCV replicons resistant to NS3, NS4b, NS5a and NS5b inhibitors.
3-V Biosciences Presents Positive Preclinical Data On HCV Product Candidates Targeting FASN At The American Association For The Study Of Liver Disease Annual Meeting 2012
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