Interim Phase II Data Of Merck's Investigational MK-5172 In Combination Therapy In Chronic Hepatitis C Virus Genotype 1 Infection To Be Presented At The American Association For The Study Of Liver Diseases (AASLD) Annual Meeting
BOC, boceprevir; PR, peginterferon alfa-2b + ribavirin; SC, second cohort; VC, vanguard cohort.
*Patients receiving the 400 mg and 800 mg doses in the SC were down-dosed to receive 100 mg in an open-label fashion. Down dosing occurred in the SC at various time points while on MK-5172. No patients were dosed down in the VC.
Of those patients with bilirubin elevation, 92 percent (22/24) occurred within the first seven to 23 days of therapy, and their bilirubin levels decreased from peak levels despite continued dosing.
Patients With Late ALT/AST Elevations
|Arm 1||Arm 2||Arm 3 (N=67)||Arm 4 (N=65)||Arm 5|
|100 mg+ PR||200 mg+ PR||MK-5172||MK-5172||MK-5172||MK-5172|
|400 mg+ PR||400 mg+ PR||800 mg+ PR||800 mg+ PR||100 mg+ PR|
|Patientswith LateALT/AST> 2x ULN||1 (2%)||6 (9%)||5 (21%)||8 (19%)||7 (24%)||8 (22%)||1 (2%)|
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