Interim Phase II Data Of Merck's Investigational MK-5172 In Combination Therapy In Chronic Hepatitis C Virus Genotype 1 Infection To Be Presented At The American Association For The Study Of Liver Diseases (AASLD) Annual Meeting
In the MK-5172 arms of the study, there were two transient liver abnormalities observed – early elevations in total bilirubin before TW 4, associated with normalization of alanine aminotransferase/aspartate aminotransferase (ALT/AST) levels, and late elevations in liver transaminases (ALT/AST) occurring after TW 4.
Patients with Early Total Bilirubin Elevations
|Arm 1||Arm 2||Arm 3 (N=67)||Arm 4 (N=65)||Arm 5|
|100 mg+ PR||200 mg+ PR||MK-5172||MK-5172||MK-5172||MK-5172||800 mg tid+ PR|
|400 mg+ PR||400 mg+ PR||800 mg+ PR||800 mg+ PR|
|TotalBilirubin >2 x ULN||1 (1.5%)||8 (11.8%)||2 (8.3%)||4 (9.3%)||2 (6.9%)||7 (19.2%)||2 (3.0%)|
PR, peginterferon alfa-2b + ribavirin; ULN, upper limit of normal.
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