This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
Stocks Under $10 with 50-100% upside potential - 14 days FREE!

Affymetrix Introduces Axiom® MiRNA Target Site Genotyping Arrays

Affymetrix, Inc. (NASDAQ:AFFX) introduces Axiom® miRNA Target Site Genotyping Arrays, the only high-density genotyping tools for genome-wide evaluation of microRNA (miRNA) target sites. These new arrays will enable comprehensive studies to elucidate how genomic variation in miRNA regulatory machinery influences gene expression and disease risk. It interrogates 238,000 SNPs and indels in genes for all parts of the miRNA cascade including miRNAs, their mRNA target sites, and silencing machinery.

Last month the Encyclopedia of DNA Elements (ENCODE) Consortium, an international collaboration of research groups funded by the National Human Genome Research Institute, reported exciting data upending the view that large portions of the human genome contain “junk” DNA. This non-coding genetic content has been shown to play a larger role in complex diseases than previously thought. “We now realize that a portion of this non-coding DNA is highly relevant in the regulation of translation and plays a role in health and disease,” stated Andy Last, PhD, Executive Vice President of Genetic Analysis and Clinical Applications Business Unit at Affymetrix. “These new arrays are powerful tools for performing large scale genomic analysis of these important regulatory miRNA elements potentially involved in complex disease.”

These genotyping arrays will complement Affymetrix’ suite of miRNA expression analysis products, including GeneChip ® miRNA 3.0 Array, QuantiGene ® 2.0 miRNA Assay, and QuantiGene ® ViewRNA in situ Hybridization (ISH) Cell Assay, which enable comprehensive and integrated analysis to advance our understanding of the role of gene regulation in health and disease. Over 80 percent of the content on the new Axiom ® miRNA Target Site Genotyping Arrays is not found on other widely used genotyping arrays and will enable scientists to survey their sample cohorts against important new content and supplement their existing association studies via meta-analysis.

“The studies we are performing using the Axiom ® miRNA Target Site Genotyping Array are showing promising results,” stated Professor Stephen B. Gruber, M.D., Ph.D., M.P.H., Director of the USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California. “We believe this array, focused on detecting variation in miRNA regulatory machinery, represents a new opportunity to broadly interrogate an important class of variants relevant to cancer research.”

In addition to the predesigned catalog version, customers can easily choose to add their own content to Axiom ® miRNA Target Site Genotyping Arrays, including variants in long non-coding RNAs for disease association studies.

Preliminary studies with the new array will be presented at the 2012 annual meeting of the American Society of Human Genetics (ASHG) in San Francisco at 10:40 a.m. on November 10, 2012. The talk, entitled “Case-control study of microRNA target site polymorphisms and colorectal cancer in the Ashkenazi Jewish population” will be presented by Dr. Michael Shapero, Sr. Director of Molecular Genetics, Affymetrix.

1 of 2

Select the service that is right for you!

COMPARE ALL SERVICES
Action Alerts PLUS
Try it NOW

Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
  • Weekly roundups
TheStreet Quant Ratings
Try it NOW
Only $49.95/yr

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
  • Upgrade/downgrade alerts
Stocks Under $10
Try it NOW

David Peltier, uncovers low dollar stocks with extraordinary upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
  • Weekly roundups
Dividend Stock Advisor
Try it NOW

Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Alerts when market news affect the portfolio
  • Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
Real Money Pro
Try it NOW

All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.

Product Features:
  • Real Money + Doug Kass Plus 15 more Wall Street Pros
  • Intraday commentary & news
  • Ultra-actionable trading ideas
Options Profits
Try it NOW

Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • 100+ monthly options trading ideas
  • Actionable options commentary & news
  • Real-time trading community
  • Options TV
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!
DOW 16,985.52 +24.95 0.15%
S&P 500 1,979.11 +0.77 0.04%
NASDAQ 4,446.9850 -2.5790 -0.06%

Brokerage Partners

Rates from Bankrate.com

  • Mortgage
  • Credit Cards
  • Auto

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs