In mouse models of HBV infection, a single injection of ARC-520 containing NAG-polymer and chol-siRNAs targeting conserved regions of the HBV transcripts resulted in multi-log reductions in circulating viral antigens and HBV DNA, and dramatically reduced HBV RNA and DNA replicative intermediates in the liver. The duration of effect is unprecedented, with HBsAg reduced >99% for one month following a single injection. These results suggest that ARC-520 holds great promise as a new therapeutic modality for patients chronically infected with HBV.About Arrowhead Research Corporation
Arrowhead Presents Data Showing 99% Target Knockdown In Monkeys Without Toxicity Using Subcutaneous Formulation Of Dynamic Polyconjugate SiRNA Delivery System
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