This Day On The Street
Continue to site right-arrow
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
Stocks Under $10 with 50-100% upside potential - 14 days FREE!

Synergy Pharmaceuticals Highlights Mechanistic Features Of Plecanatide, A Novel Investigational Drug For Chronic Idiopathic Constipation

Stocks in this article: SGYP

NEW YORK, Oct. 22, 2012 (GLOBE NEWSWIRE) -- Synergy Pharmaceuticals Inc. (Nasdaq:SGYP), a developer of new drugs to treat gastrointestinal disorders and diseases, today announced the preclinical findings being presented by Synergy scientists at two key gastroenterology congresses this week.

The scientific poster presentations describe the site of action and other mechanistic features of plecanatide, Synergy's investigational drug for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). Plecanatide is an agonist of the guanylate cyclase-C receptor and an analog of the natriuretic peptide, uroguanylin, the physiologic ligand of GC-C. As a uroguanylin analog, plecanatide is a member of a new class of non-systemic oral drugs, known as guanylate cyclase-C (GC-C) agonists, that act locally to promote intestinal fluid secretion.

"These preclinical studies helped to define plecanatide as a superior candidate for clinical testing in patients with chronic constipation," said Dr. Kunwar Shailubhai, Chief Scientific Officer of Synergy Pharmaceuticals, who is presenting the data at the America College of Gastroenterology annual meeting in Las Vegas, NV this week.

"In phase I and early phase II clinical testing, plecanatide exhibited an excellent safety profile, and patients in the phase IIa trial experienced relief from constipation without any remarkable diarrhea," said Stephen Comiskey, Synergy's Vice President for Product Development, who is presenting the preclinical data at the 20 th United European Gastroenterology Week in Amsterdam, The Netherlands this week. "This summer Synergy achieved target enrollment in an ongoing phase IIb/III clinical trial of plecanatide in patients with chronic constipation, and we look forward to the results later this year."

Key preclinical findings being presented that informed the clinical testing of plecanatide as an optimal drug candidate include:

  • Orally administered plecanatide acts primarily in the proximal intestine to stimulate water secretion essential for normalizing bowel movement.
  • In vitro binding studies demonstrate that plecanatide binds to the same receptors in the proximal intestine as human uroguanylin.
  • Plecanatide is highly stable and potent, with even greater affinity for the human GC-C receptors than the natural uroguanylin hormone.

"There is a compelling need to find safe and effective treatments for patients with CIC," said Douglas Drossman, Adjunct Professor of Medicine and Psychiatry and Co-Director Emeritus, UNC Center for Functional GI and Motility Disorders, UNC School of Medicine. "I am encouraged by the preclinical and early phase clinical data that demonstrate proof of concept for plecanatide as a treatment approach for chronic constipation, and look forward to seeing data from the ongoing trials."

1 of 3

Select the service that is right for you!

Action Alerts PLUS
Try it NOW

Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
  • Weekly roundups
TheStreet Quant Ratings
Try it NOW
Only $49.95/yr

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
  • Upgrade/downgrade alerts
Stocks Under $10
Try it NOW

David Peltier, uncovers low dollar stocks with extraordinary upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
  • Weekly roundups
Dividend Stock Advisor
Try it NOW

Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Alerts when market news affect the portfolio
  • Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
Real Money Pro
Try it NOW

All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.

Product Features:
  • Real Money + Doug Kass Plus 15 more Wall Street Pros
  • Intraday commentary & news
  • Ultra-actionable trading ideas
Options Profits
Try it NOW

Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • 100+ monthly options trading ideas
  • Actionable options commentary & news
  • Real-time trading community
  • Options TV
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!


DOW 17,804.80 +26.65 0.15%
S&P 500 2,070.65 +9.42 0.46%
NASDAQ 4,765.38 +16.9840 0.36%

Brokerage Partners

Rates from

  • Mortgage
  • Credit Cards
  • Auto

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs