These results are encouraging, as they follow the recent regulatory approvals in the U.S. and Europe of HUMIRA for inducing and sustaining clinical remission in adult patients with moderately to severely active UC who demonstrated an inadequate response to immunosuppressant therapy," said John Medich, Ph.D., divisional vice president, clinical development, Immunology, Abbott. "Abbott is committed to further investigate the long-term use, efficacy and safety of HUMIRA in these patients."Study Details The analysis of the ULTRA 1 and ULTRA 2 trials and the ongoing, multicenter open-label extension evaluated the long-term treatment of HUMIRA in patients with moderately to severely active UC for up to three years (172 weeks). Partial Mayo score (PMS), which evaluates stool frequency, rectal bleeding, and physician's global assessment, was collected at every study visit during the trials and the open-label extension. Mean PMS over time from first dose of HUMIRA was assessed using observed case method and decreased over time through 172 weeks of treatment from 5.9 (n=992) to 1.4 (n=136).
Abbott Announces Three-Year Long-Term Data Evaluating Efficacy With HUMIRA® (Adalimumab) For Patients With Moderately To Severely Active Ulcerative Colitis
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