This Day On The Street
Continue to site
ADVERTISEMENT
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here

Abbott Hep C Therapy Achieves Almost-Perfect Cure Rate

ABBOTT PARK, Ill. ( TheStreet) -- A combination regimen of oral hepatitis C drugs developed by Abbott (ABT - Get Report) achieved near-perfect cure rates in patients new to treatment. Cure rates were almost as strong in patients who failed previous therapy, making them among the hardest to treat.

With cure rates of 99% following a 12-week regimen of oral drugs, Abbott stamps itself as a strong challenger to Gilead Sciences (GILD - Get Report) in the rapidly evolving race to develop potent, interferon-free regimens for hepatitis C.

Abbott shares rose more than 3% to $71.60 following the release of the hepatitis C data.

The new Abbott data announced Monday come from a large, phase II study known as "AVIATOR" that was designed to assess the efficacy and safety of various combinations of oral hepatitis drugs in treatment-naive patients as well as hard-to-treat "null" responders.

The Abbott drugs studied in AVIATOR were ABT-450, a protease inhibitor that requires blood-boosting with ritonavir; ABT-267, a NS5A inhibitor; and ABT-333, a "non-nuc" polymerase inhibitor. Ribavirin, a current backbone in hepatitis C treatment, was also included in some but not all of the combination regimens.

A 12-week regimen consisting of all three Abbott drugs plus ribavirin demonstrated "observed" SVR12 rates of 99% (76/77) in treatment-naive patients and 93% (38/41) in null responders. [SVR12 is the scientific jargon for a cure and measures the percent of patients who have undetectable hepatitis C virus in their system 12 weeks after treatment ends.]

The "observed" SVR12 results omit two treatment-naive patients and four null responder patients with either missing data or inadequate follow-up. If those patients were included and all failed to achieve an SVR12 cure -- a worst-case scenario -- the treatment-naive and null responder cure rates would drop to 96% and 84%, respectively.

Sixty-six percent of the patients enrolled in the Abbott study has genotype 1A virus, considered more resistant to treatment than genotype 1b. Similarly, 70% of patients had unfavorable "non-CC" genetics.

The AVIATOR study also treated patients with regimens consisting of two (not three) Abbott drugs with ribavirin, some with shortened treatment to eight weeks (not 12 weeks.) SVR12 cure rates in these various arms of the study ranged from 89-92%, Abbott announced.

More detailed data from the AVIATOR study will be presented in November at the American Association for the Study of Liver Disease (AASLD) annual meeting.
1 of 2

Check Out Our Best Services for Investors

Action Alerts PLUS

Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
Quant Ratings

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
Stocks Under $10

David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
14-Days Free
Only $9.95
14-Days Free
Dividend Stock Advisor

David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks

Every recommendation goes through 3 layers of intense scrutiny—quantitative, fundamental and technical analysis—to maximize profit potential and minimize risk.

Product Features:
  • Model Portfolio
  • Intra Day Trade alerts
  • Access to Quant Ratings
Options Profits

Our options trading pros provide over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • Actionable options commentary and news
  • Real-time trading community
SYM TRADE IT LAST %CHG
ABT $50.77 -0.57%
BMY $64.46 -0.66%
GILD $117.90 1.89%
VRTX $135.46 7.83%
AAPL $122.37 -0.50%

Markets

Chart of I:DJI
DOW 17,745.98 -5.41 -0.03%
S&P 500 2,108.63 +0.06 0.00%
NASDAQ 5,128.7850 +17.0520 0.33%

Free Reports

Top Rated Stocks Top Rated Funds Top Rated ETFs