- OPTION (T Ocilizumab Pivotal Trial in methotrexate Inadequate resp ONders) trial:
- 59 percent and 48 percent of patients who received ACTEMRA 8 mg/kg and 4 mg/kg plus MTX, respectively, achieved ACR20 at Week 24, compared with 27 percent of patients who received placebo plus MTX
- TOWARD ( Tocilizumab in c Ombination With traditional DM ARD therapy) trial:
- 61 percent of patients who received ACTEMRA 8 mg/kg plus DMARD(s) achieved ACR20 at Week 24, compared with 25 percent of patients treated with DMARDs plus placebo
- LITHE (Toci LIzumab safety and THE prevention of structural joint damage) trial:
- 56 percent and 51 percent of patients who received ACTEMRA 8 mg/kg or 4 mg/kg plus MTX, respectively, achieved ACR20 at Week 24 compared with 27 percent of patients who received placebo plus MTX. In addition, ACTEMRA 4 mg/kg slowed (less than 75 percent inhibition compared to the control group) and ACTEMRA 8 mg/kg inhibited (at least 75 percent inhibition compared to the control group) the progression of structural damage compared to placebo plus MTX at week 52, as measured by change in total Sharp-Genant score.
FDA Approves Expanded Indication For ACTEMRA® In Rheumatoid Arthritis
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