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Updated Phase 2 Survival Data Of Cyclacel's Sapacitabine For MDS Presented At The Eighth Annual Hematologic Malignancies 2012 Conference

Study Design

The open-label, multi-center, Phase 2 study randomized 63 patients aged 60 years or older with MDS of intermediate-2 (n=52) or high-risk (n=11) classification by the International Prognostic Scoring System (IPSS) at study entry to receive sapacitabine every 4 weeks on one of 3 dosing schedules: 200 mg twice daily for 7 days (Arm G), 300 mg once daily for 7 days (Arm H), or 100 mg once daily for 5 days per week for 2 weeks (Arm I). The primary efficacy endpoint of the study is 1-year survival with the objective of identifying a dosing schedule that produces a better 1-year survival rate in the event that all three dosing schedules are active. All patients in the study progressed after receiving azacitidine, decitabine, or both agents.

The Eighth Annual Hematologic Malignancies 2012 Conference

Information on The Eighth Annual Hematologic Malignancies 2012 Conference can be at accessed at: http://hm2012.homestead.com . Presentation times are as follows:

Session IV: Myelodysplastic Syndromes I
Guillermo Garcia-Manero, MD: "New MDS Strategies"
Date/Time: Thursday, October 11, 2012, 5:40 PM Central
 
Session X: Myelodysplastic Syndromes II
Hagop Kantarjian, MD: "Keynote Speaker: MDS/MPD (with award from MDACC 1/Mayo Clinic)"
Date/Time: Saturday, October 13, 2012, 4:00 PM Central
 
Guillermo Garcia-Manero, MD and Hagop Kantarjian, MD will discuss on a Company conference call the updated data from the above presentations. Conference call details are as follows:
 
Date/Time: Monday, October 15, 2012, 3:30 PM Eastern
US/Canada call: (877) 493-9121/ international call: (973) 582-2750
US/Canada archive: (800) 585-8367 / international archive: (404) 537-3406
Code for live and archived conference call is 44048598 

About Myelodysplastic Syndromes (MDS)

MDS is a family of clonal myeloid neoplasms, or malignancies of the blood, caused by the failure of blood cells in the bone marrow to develop into mature cells. Patients with MDS typically suffer from bone marrow failure and cytopenias, or reduced counts of platelets, red and white blood cells. The exact incidence and prevalence of MDS are unknown because it can go undiagnosed and a national survey canvassing both hospitals and office practitioners has not been completed. Some estimates place MDS incidence at 15,000 to 20,000 new cases each year in the US alone with some authors estimating incidence as high as 46,000. Literature evidence suggests that there is a rising incidence of MDS as the age of the population increases with the majority of patients aged above 60 years.

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