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Oculus Innovative Sciences Announces Results From Study Of Microcyn(R) Technology-Based Atrapro(TM) Antipruritic Hydrogel Used In Combination With Neosalus(R) Cream In Treatment Of Atopic Dermatitis

PETALUMA, Calif., Oct. 9, 2012 (GLOBE NEWSWIRE) -- Oculus Innovative Sciences, Inc. (Nasdaq:OCLS), today announced results of a multicenter, prospective and open-label pilot study in which Microcyn® Technology-based Atrapro™ Antipruritic Hydrogel was evaluated in combination with Neosalus® Cream in the treatment of atopic dermatitis. The two products are frequently marketed as a comprehensive treatment regimen for skin dermatoses including atopic dermatitis.

Oculus licensed the Microcyn Technology-based products for treatment of atopic dermatitis in the United States to Quinnova Pharmaceuticals in February 2011. The lead product, branded as Atrapro™ Antipruritic Hydrogel, was introduced to U.S. dermatologists in February 2012. The Neosalus Cream was commercialized by Quinnova in 2010.

The primary objective of the study, presented in a poster by authors Joseph F. Fowler, Jr, MD, Miriam S. Bettencourt, MD, and Stephen M. Schleicher, MD, at the 2012 Fall Dermatology Conference in Las Vegas this past week, was to evaluate efficacy in providing symptomatic relief among atopic dermatitis patients treated with these two products. A secondary objective evaluated whether the order of product application affected the clinical outcome. Eighteen patients completed the study.

The following assessments were used to evaluate efficacy and symptomatic relief associated with the use of the two products:
  • Change in body surface area (BSA) and target lesion area affected with atopic dermatitis from baseline to week 2 and week 4.
  • Change in several investigator assessments (ISGA) of the symptoms of atopic dermatitis, measured from baseline to week 2 and week 4.
  • Improvement of scores in the patients' evaluation of signs and symptoms of atopic dermatitis; including burning, dryness, pain, itch, and redness.

Patients were directed to apply the cream and the hydrogel sequentially, three times daily to the affected areas of the skin. Patients were assigned randomly into two order-of-application treatment groups: cream first, hydrogel second or the hydrogel first, cream second. The second product was applied immediately after the first product was dry. Patients were evaluated at baseline, week 2, and week 4 (end of treatment).

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