Teva Pharmaceutical Industries Ltd. (NYSE: TEVA) today announced that key data from the Company’s multiple sclerosis (MS) franchise will be featured at the 28 th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) in Lyon, France, October 10-13, 2012. Data presentations will provide new insights on COPAXONE ® (glatiramer acetate injection), the world’s leading relapsing-remitting multiple sclerosis (RRMS) treatment, and Teva’s investigational oral compound laquinimod, as well as results from the ongoing TOP MS and NARCOMS studies.
"For more than 20, years Teva has been at the forefront of MS research and development focused on providing effective and safe treatments aimed at meeting the needs of patients’ living with this complex, often debilitating disease,” said Dr. Michael Hayden, President of Global R&D and Chief Scientific Officer for Teva Pharmaceutical Industries Ltd. “The data being presented at ECTRIMS demonstrate our ongoing commitment to enhancing the treatment experience for RRMS patients and advancing science to assist neurologists in making appropriate treatment decisions, especially as the market continues to evolve.”
In addition to the data being presented at the Congress, Teva will host a satellite symposium, “New Concepts in MS Pathology Shed Light on MS Treatment Approaches” on Thursday, October 11, 2012 from 19:15 - 20:15 CET. Teva will also host a media event for credentialed journalists on Thursday, October 11, 2012 at 12:00 CET focused on advancements made in RRMS and future considerations for treatment.
Teva-Sponsored Data Highlights Include:Glatiramer Acetate: The multinational randomized, double-blind placebo-controlled Phase III Glatiramer Acetate Low-frequency Administration (GALA) study examined the efficacy, safety and tolerability of an investigational formulation of glatiramer acetate 40 mg/1 ml administered three times a week compared to placebo in a randomized, double-blind placebo-controlled design in patients with RRMS. A late-breaking news parallel session will present detailed clinical data on October 13, 2012, while a poster presentation will analyze baseline patient demographics for this trial. Key posters include:
- [P 912] A multinational, multicenter, randomized, parallel-group study to access efficacy, safety and tolerability of Glatiramer Acetate 40 mg injection three times a week in subjects with RRMS: Baseline Patient Characteristics of the GALA study (Poster Session 2: Immunomodulation, October 12, 15:30 - 17:00 CET) O. Khan, P. Rieckmann, A. Boyko, K. Selmaj, R. Zivadinov (Detroit, US; Bamberg, DE; Moscow, RU; Lodz, PL; Buffalo, US)
-  A phase 3 trial to assess the efficacy and safety of glatiramer acetate injections 40mg administered 3 times a week compared to placebo (Parallel Session 13: Late Breaking News, October 13, 8:30 – 8:45 CET) O. Khan, P. Rieckmann, A. Boyko, K. Selmaj, R. Zivadinov (Detroit, US; Bamberg/Erlangen, DE; Moscow, RU; Lodz, PL; Buffalo, US)
- [P 516] Oral laquinimod in patients with relapsing-remitting multiple sclerosis: Clinical effects at 36 months in the open-label extension phase of the ALLEGRO study (Poster Session 1: Long-term Treatment Monitoring, October 11, 15:30 – 17:00 CET) G. Comi, D. Jeffery, L. Kappos, X. Montalban, A.N. Boyko, M.A. Rocca, M. Filippi on behalf of the ALLEGRO Study Group
- [P 762] Assessing prognostic factors of severe relapse requiring hospitalisation and/or IV methylprednisolone in RRMS treated with placebo or laquinimod: pooled analysis from the ALLEGRO and BRAVO trials (Poster Session 2: Economic Burden, October 12, 15:30 – 17:00 CET) C.A. Carroll, P. Lindgren, A. Lang on behalf of the Allegro & BRAVO Study Group
- [P 861] Evidence for a neuroprotective effect of oral laquinimod in relapsing remitting multiple sclerosis (Poster Session 2: Imaging, October 12, 15:30 – 17:00 CET) M. Filippi, M.A. Rocca, N. De Stefano, D. Jeffery, L. Kappos, X. Montalban, A.N. Boyko, G. Comi on behalf of the ALLEGRO Study Group
- [P 260] Relationship between MS therapy adherence and relapse episodes (Poster Session 1: Databases and Pharmacoepidemiology, October 11, 15:30 – 17:00 CET) T. Leist, H. Zwibel, M. Schwartz, B. Cohen, M. Tullman, P. K. Coyle on behalf of the TOP MS Steering Committee
- [P 1035] Predictors of change in work productivity and activity impairment scores (Poster Session 2: Comprehensive Care and Rehabilitation) M. Tullman, T. Leist, H. Zwibel, B. Cohen, P.K. Coyle, M. Lage on behalf of the TOP MS Study Steering Committee
- [P 698] Comparative effectiveness of long-term users of disease-modifying therapy (Poster Session 2: Epidemiology, October 12, 15:30 – 17:00 CET) A. Salter, Y. Tang, L. Hornung, S. Kolodny, D. Hurtukova, S. Glenski, S. Cofield, X. Zhang, G. Cutter (Birmingham, Kansas City, US)