This Day On The Street
Continue to site
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here

Merrimack Pharmaceuticals' Therapies Show Promise In Certain Advanced Breast, Gastric And Gynecologic Cancers

CAMBRIDGE, Mass., Oct. 2, 2012 /PRNewswire/ -- Merrimack Pharmaceuticals, Inc. (NASDAQ: MACK) today announced the presentation of Phase 1 safety and clinical results evaluating two potential new therapies with a novel target – ErbB3, a signaling receptor believed to be responsible for triggering tumor growth and resistance in a number of malignancies including breast, ovarian, gastric, esophageal and bladder cancers. The two studies were presented in poster sessions at the European Society for Medical Oncology (ESMO) in Vienna, Austria.

To view the multimedia assets associated with this release, please click:

The separate studies were testing the safety profiles of (1) MM-121, developed in collaboration with Sanofi, in a combination regimen with weekly paclitaxel in advanced metastatic breast and ovarian cancers and (2) MM-111 in multiple HER2-Targeting regimens in advanced HER2 positive (ErbB2+ or HER2+) solid tumors.  Each study demonstrated a promising clinical benefit rate for the MM-121 and MM-111 combination regimens, a secondary endpoint for each of the studies.  MM-121 and MM-111 each employ their own unique mechanisms to stop ligand-driven activation of ErbB3 from signaling the cancer cell to grow.

"We are pleased to see signs of clinical benefit in our studies with MM-121 and MM-111 across a broad range of solid tumors in patients who have progressed on standard of care therapies," said Robert J. Mulroy, President and Chief Executive Officer, Merrimack Pharmaceuticals.  "Both candidates emerged from our Network Biology research engine, in which we identified ErbB3 as a central growth signaling node.  Given their unique approaches to targeting ErbB3 biology, we believe that MM-121 and MM-111 are important therapies to advance the treatment of cancer and we are excited to watch them progress through clinical development."

A Phase 1 Study of the Anti-ErbB3 Antibody MM-121 in Combination with Weekly Paclitaxel in Patients with Advanced Gynecologic and Breast Cancers (Abstract #: 974PD)

The study evaluated MM-121, a fully human monoclonal antibody, in combination with weekly paclitaxel, a standard regimen for patients with advanced gynecological and metastatic breast cancers.

1 of 4

Check Out Our Best Services for Investors

Action Alerts PLUS

Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
Quant Ratings

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
Stocks Under $10

David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
14-Days Free
Only $9.95
14-Days Free
Dividend Stock Advisor

David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks

Every recommendation goes through 3 layers of intense scrutiny—quantitative, fundamental and technical analysis—to maximize profit potential and minimize risk.

Product Features:
  • Model Portfolio
  • Intra Day Trade alerts
  • Access to Quant Ratings
Real Money

More than 30 investing pros with skin in the game give you actionable insight and investment ideas.

Product Features:
  • Access to Jim Cramer's daily blog
  • Intraday commentary and news
  • Real-time trading forums
Only $49.95
14-Days Free
14-Days Free
AAPL $92.65 -0.63%
FB $119.06 1.10%
GOOG $709.28 1.10%
YHOO $37.26 0.87%
TSLA $215.14 1.70%


Chart of I:DJI
DOW 17,738.27 +77.56 0.44%
S&P 500 2,056.21 +5.58 0.27%
NASDAQ 4,729.1080 +12.0140 0.25%

Free Reports

Top Rated Stocks Top Rated Funds Top Rated ETFs