"We are very fortunate to have the opportunity to participate in these projects and explore the potential benefits of KL 4 surfactant to address unmet needs in acute lung injury," said Dr. Robert Segal, Sr. Vice President, Government and Academic Affairs at Discovery Labs. "While our short-term development priority is focused on neonatology applications, efforts such as these demonstrate the potential to apply and develop our technologies to advance new standards in respiratory critical care."ALI is associated with conditions that either directly or indirectly injure the air sacs of the lung. ALI is a syndrome of inflammation and increased permeability of the lungs with an associated breakdown of the lungs' surfactant layer. Among the causes of ALI are complications typically associated with certain major surgeries, mechanical ventilator-induced lung injury (often referred to as VILI), severe acute respiratory syndrome (SARS), pneumonia and sepsis. Direct injury of the lung leading to ALI can also occur from radiation or caustic chemical exposure. There are a significant number of people at risk in the United States for ALI annually and there are no currently approved therapies other than supportive respiratory care. Despite recent advances in understanding the pathophysiology, treatment, and long-term outcome of acute lung injury, morbidity and mortality related to ALI remains high.
Discovery Labs Initiates Research Projects With Leading Research Institutions And US Government Agencies To Assess KL(4) Surfactant Utility In Acute Lung Injury
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