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Biotech Stock Mailbag: Pending Sarepta Results, Cyclacel

Also in last week's Mailbag, I mentioned Clovis Oncology (CLVS) as a company I liked after seeing the company present at a recent investor conference. This prompted an email from a buyside investor who's not a fan of Clovis' pancreatic cancer drug CO-101. I'm not allowed to use his name but his comments accurately describe the Clovis bear thesis:

"If you read the published papers, particularly the in vitro and animal data, you can see that this is a sure failure. The Clovis drug [CO-101] becomes free gemcitabine about 15 minutes after it enters the body. They also left off that under normal circumstances it takes 10 times the dose and 2 times the time for the Clovis drug to produce the same active form of gemcitabine inside the cell as it does with normal gemcitabine. Finally, the Clovis drug did slightly worse than gemcitabine in animals with tumors that have the blocked channel Clovis supposedly overcomes," this Clovis bear writes.

Clovis is expected to announce top-line results from a phase III study of CO-101 in pancreatic cancer before the end of the year.

--Written by Adam Feuerstein in Boston.

>To contact the writer of this article, click here: Adam Feuerstein.

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Adam Feuerstein writes regularly for TheStreet. In keeping with company editorial policy, he doesn't own or short individual stocks, although he owns stock in TheStreet. He also doesn't invest in hedge funds or other private investment partnerships. Feuerstein appreciates your feedback; click here to send him an email.
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