This Day On The Street
Continue to site right-arrow
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
Stocks Under $10 with 50-100% upside potential - 14 days FREE!

Apricus Biosciences Announces Publication In Journal Of Pharmaceutics And Drug Delivery Research

Stocks in this article: APRI

SAN DIEGO, Sept. 17, 2012 (GLOBE NEWSWIRE) -- Apricus Biosciences, Inc. ("Apricus Bio" or the "Company") (Nasdaq:APRI) ( ) announced today publication in the current issue of the Journal of Pharmaceutics and Drug Delivery Research of an article featuring Tolnaftate-D , the Company's over-the-counter ("OTC") antifungal product for the treatment of Athlete's Foot. The paper, entitled "Enhancing the Skin Flux of Tolnaftate Utilizing the Novel Excipient, Dodecyl-2-N,N-Dimethylaminopropionate (DDAIP)," was written by Susan R. Meier-Davis, DVM, PhD, DABT, RAC, the Company's Vice President of Safety. The published data demonstrates that Tolnaftate-D , Apricus Bio's novel tolnaftate formulation (tolnaftate 1% delivered using 0.5% DDAIP), resulted in a significant (57%) increase in penetration over a 24-hour period as compared to OTC tolnaftate 1%. The full article is available online at .

Tolnaftate 1% is a widely used antifungal agent that is regarded by the FDA as generally recognized as safe and effective ("GRASE") as an OTC treatment for superficial fungal infections including Athlete's Foot, ringworm and jock itch. The customary treatment regimen is topical application of tolnaftate 1% cream on the affected area, twice daily. Penetration of an antifungal drug through the stratum corneum to reach the underlying epidermal and dermal layers is needed for effective topical treatment of fungal infections. To enhance the permeation of tolnaftate, Apricus Bio's Tolnaftate-D contains NexACT ®, its novel penetration enhancer, and tolnaftate 1%. Utilizing human cadaver skin mounted on Franz cells, tolnaftate skin flux was evaluated with and without the presence of NexACT ®. The mean cumulative flux of tolnaftate 1% in 0.5% DDAIP over the 24-hour evaluation period was increased more than 3 times compared to 1% tolnaftate alone.

"Increased penetration of tolnaftate has the potential to reduce the number of applications and overall treatment duration necessary to clear a fungal infection," said Bassam Damaj, PhD, President and Chief Executive Officer of Apricus Bio. "In addition, resistance to antifungal therapy increases with duration of treatment, so development of a tolnaftate formulation with increased epidermal penetration could also decrease the potential for organism resistance. This publication is yet another example of the broadly applicable nature of our NexACT ® drug delivery technology."

About OTC Tolnaftate-D and NexACT ®

Tolnaftate-D is Apricus Bio's first OTC antifungal product. The product incorporates tolnaftate 1% and NexACT ®, the Company's proprietary drug delivery technology that transiently loosens the tight junctions between skin cells to enhance permeation. DDAIP is a drug excipient and may be used with other GRASE active ingredients listed in final FDA OTC monographs to create and develop other potential proprietary OTC products. The Company filed for approval of its Tolnaftate-D OTC product in Canada and is currently awaiting potential approval from the authorities in that country.

About Apricus Biosciences, Inc.

Apricus Bio (Nasdaq:APRI) is a pharmaceutical company that develops and markets innovative treatments that help large patient populations across numerous, high-demand therapeutic classes. The Company has four approved products and has developed a strong pipeline of multiple late-stage product opportunities. With commercial operations in both the U.S. and Europe (France), Apricus Bio generates revenues and growth from sales of its commercial products and by out-licensing, in certain territories, its pipeline products and NexACT ® technology.

Apricus Bio's growth strategy is to acquire, develop, and commercialize new products through strategic partnerships. The Company currently has commercial partnerships with multiple large pharmaceutical companies including Novartis, Abbott Laboratories, Takeda, Sandoz, Warner Chilcott and Bracco, and co-promotes multiple products in France.

1 of 2

Select the service that is right for you!

Action Alerts PLUS
Try it NOW

Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
  • Weekly roundups
TheStreet Quant Ratings
Try it NOW
Only $49.95/yr

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
  • Upgrade/downgrade alerts
Stocks Under $10
Try it NOW

David Peltier, uncovers low dollar stocks with extraordinary upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
  • Weekly roundups
Dividend Stock Advisor
Try it NOW

Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Alerts when market news affect the portfolio
  • Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
Real Money Pro
Try it NOW

All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.

Product Features:
  • Real Money + Doug Kass Plus 15 more Wall Street Pros
  • Intraday commentary & news
  • Ultra-actionable trading ideas
Options Profits
Try it NOW

Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • 100+ monthly options trading ideas
  • Actionable options commentary & news
  • Real-time trading community
  • Options TV
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!


DOW 17,804.80 +26.65 0.15%
S&P 500 2,070.65 +9.42 0.46%
NASDAQ 4,765.38 +16.9840 0.36%

Brokerage Partners

Rates from

  • Mortgage
  • Credit Cards
  • Auto

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs